the reaction of 3-chloropropyl boehmite nanoparticles with caffeine and sulfuric acid afforded bnps-3-propyl-imidazolopyridinium hydrogen sulfate [bnps-caff]hso4 as a new bnps-supported ionic liquid (il) catalyst. [bnps-caff]hso4 proved to be an efficient heterogeneous catalyst for the synthesis of pyrazolopyranopyrimidines via a one-pot four-component reaction of hydrazine hydrate, ethyl aceto...

Treatment (>/=24 h) of cultured bovine adrenal chromaffin cells with ketoacidosis-related concentrations (>/=3 mM) of acetoacetate (but not beta-hydroxybutyrate, acetone, and acidic medium) caused a time- and concentration-dependent reduction of cell surface (125)I-insulin binding by ~38%, with no change in the K(d) value. The reduction of (125)I-insulin binding returned to control nontreated l...

Previously, we have shown the preferential incorporation of label from [3-‘%]acetoacetate, D-( -)-3-hydroxy[3-%]butyrate, and [2-‘4C]glucose into sterols and fatty acids in brain in Id-day-old rats. In these experiments, we assumed that the labeled metabolites would be used from the blood in the form which was injected. However, during metabolic processes, a labeled metabolite which is present ...

In the present study, a set of different benzoxazole derivatives has been synthesized from ethyl acetoacetate, ethoxymethylene malononitrile, NaNO2, and organic acids. Analytical instruments like proton NMR (1H), carbon (13C), infrared spectroscopy (IR), LC-MS mass spectrometry were used for structural characterization. Synthesized molecules evaluated In-vitro antioxidant property (DPPH assay, ...

An increased prevalence of liver diseases such as hepatitis C and nonalcoholic fatty liver results in an augmented incidence of the most common form of liver cancer, hepatocellular carcinoma (HCC). HCC is most often found in the cirrhotic liver and it can therefore be challenging to rely on anatomical information alone when diagnosing HCC. Valuable information on specific cellular metabolism ca...

a simple and efficient method for the synthesis of quinolines and polycyclic quinolines using li+ modified nanoporous na+-montmorillonite is described. this new nanocatalyst proceeds via friedlander annulation under solvent-free conditions. it describes our observations about a trend of catalytic activity of lithium cation in nanoporous na+-montmorillonite. in this study, several types of 1,3-d...

a mild and green method has been developed for the preparation of coumarins derivatives through the one-pot reactions. in our study,various phenols and ethyl acetoacetate compound in which we used silica-supported boron sulfonic acid [sio2/b(so4h)3] as a new, highly efficient and tri-functional inorganic brønsted acid catalyst were processed under solvent-free condition and thermal. the catalys...

the fe-mcm-22 zeolite was found to be an efficient solid heterogeneous catalyst for synthesis of dihydropyrano [2,3-c] pyrazoles via one pot four component reaction of ethyl acetoacetate, hydrazine hydrate, aromatic aldehyde and malononitrile in aqueous alcohol. the catalyst was synthesized by hydrothermal method under autogenous pressure and modified by fe (iii) ion exchange. the prepared cata...

We describe an automated kinetic assay for acetoacetate in blood. Acetoacetate is enzymatically reduced to D-beta-hydroxybutyrate and the reaction is monitored for 60 s with a reaction-rate analyzer. This technique allows low concentrations of acetoacetate to be measured with good precision and overcomes many of the problems associated with other automated techniques. Our studies on the stabili...

1. The metabolic interactions between glucose, acetoacetate and adrenaline were studied in submaxillary-gland slices. 2. Acetoacetate (2.5 mM) inhibited glucose removal by 22% and entry of glucose carbon into the tricarboxylic acid cycle by 54%. 3. Acetoacetate caused an increase in (glucose 6-phosphate) together with an increase in (citrate), a finding that suggests that the phosphofructokinas...