Location 4q12 Protein Composed of an extracellular domain, a transmembrane domain, a juxtamembrane domain, and an intracellular domain; receptor tyrosine kinase; forms homodimer, and heterodimer with PDGFRB; dimerization induces kinase domain activation, leading to the activation of intracellular signalling pathways (Kawagishi et al., 1995). Somatic mutations Hybrid genes between various partne...

Modulating cytoplasmic free Ca concentration ([Ca]i) is a ubiquitous intracellular signaling pathway that regulates numerous cellular physiological processes, including apoptosis, gene expression, bioenergetics, secretion, immune responses, fertilization, muscle contraction, synaptic transmission, and learning and memory (Clapham, 1995; Berridge et al., 2000; Bootman et al., 2001; Braet et al.,...

LYP, the protein product of the protein tyrosine phosphatase gene PTPN22 located on human chromosome 1p13.2, is involved in downregulation of T cell signaling through its interaction with C-terminal Src tyrosine kinase (Csk) (Cloutier and Veillette, 1996), by phosphorylation of regulatory tyrosines on the Src family kinase Lck (Cloutier and Veillette, 1999). A missense mutation of this gene (C1...

Copyright © 2012 by The Geochemical Society of Japan. al., 1996, 2004; Zheng et al., 2000; Algeo and Lyons, 2006; Tribovillard et al., 2004, 2006), and formation or subsequent removal of these intermediates may be one way of driving variations in Mo isotope fractionation under reducing conditions (Neubert et al., 2008). In the open ocean, which is generally devoid of dissolved sulfide, Mo is pr...

In the last decade, advances in wireless communication and micro-fabrication have motivated the development of large-scale wireless sensor networks (Akyildiz et al., 2002; Yick et al., 2008). A large number of low-cost sensor nodes, equipped with sensing, computing, and communication units, organize themselves into a multi-hop network. The wireless sensor network takesmeasurements from the envi...

s only (1) Editorials (3) 4d. Number of articles/sources meeting criteria for further review: 11 4 randomized trials were identified: (Dorges et al 2000 [not CPR cases only those undergoing GA]), (Langehell et al 2000), (Wenzel et al 1999 [not CPR cases, only those undergoing GA]), (Droges et al 1999 [not CPR cases only those undergoing GA]), 4 relevant human (mechanistic) studies were identifi...

LYP, the protein product of the protein tyrosine phosphatase gene PTPN22 located on human chromosome 1p13.2, is involved in downregulation of T cell signaling through its interaction with C-terminal Src tyrosine kinase (Csk) (Cloutier and Veillette, 1996), by phosphorylation of regulatory tyrosines on the Src family kinase Lck (Cloutier and Veillette, 1999). A missense mutation of this gene (C1...

People appear to be biased in their predictions of the future; predicting that projects will take less time than they actually will (see Roy et al., 2005a; Buehler et al., 2010; Halkjelsvik and Jørgensen, 2012, for review) and that they will be unlikely to experience future misfortunes (see Dunning et al., 2004, for review). These biases are frequently attributed to people being overly optimist...

Pesticide contamination of river and lake waters from agriculture use is a problem of worldwide importance. Many field data on the pesticide contamination of surface waters and aquatic organisms in rivers and lakes (Amaraneri & Pillala, 2001, Abdel-Halim et al., 2006; Agradi et al., 2000; California Environmental Protection Agency, 2002; California Regional Water Quality Control Board, 2002; Ca...

Throughout the world, drug and alcohol use has a clear adolescent onset (Degenhardt et al., 2008). Alcohol continues to be the most popular drug among teens and emerging adults, with almost a third of 12th graders and 40% of college students reporting recent binge drinking (Johnston et al., 2009, 2010), and marijuana (MJ) is the second most popular drug in teens (Johnston et al., 2010). The ini...