It is well known that the renin-angiotensin system (RAS) is involved in the control of blood pressure. Recently, all or part of the components concerning the RAS have been reported to be synthesized and secreted outside of classical organs or tissues, at sites including the brain, pituitary and pineal glands, eye, heart, adrenal gland, testes, ovary, placenta, and coagulating glands. The functi...