By defining functional defects in a congenital myasthenic syndrome (CMS), we show that two mutant residues, located in a binding site region of the acetylcholine receptor (AChR) epsilon subunit, exert opposite effects on ACh binding and suppress channel gating. Single channel kinetic analysis reveals that the first mutation, epsilon N182Y, increases ACh affinity for receptors in the resting clo...

The notions of $${{\mathcal {N}}}$$ -ideal types $$(\in , \in )$$ and \! \vee \, {q})$$ soft $${\mathcal N}_{\in }$$ -set, {N}}}_{q}$$ {N}}}_{\in {q}}$$ -subalgebra in BCK/BCI-algebra are introduced, several properties investigated. Characterizations N}$$ discussed.

computationally, selection of a proper numerical value for infinitesimal non archimedean epsilon in dea models has some difficulties. although there are several algorithms for selecting the proper non-archimedean epsilon, it is important to introduce methods in order to calculate the efficiency of dmus without using epsilon. one of these methods is a two-phase method, which obtains the efficien...

BACKGROUND Revision of the Task Force diagnostic criteria for arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) has increased their sensitivity for the diagnosis of early and familial forms of the disease. The epsilon wave is a major diagnostic criterion in the context of ARVC/D, which, however, remains not quantifiable and therefore may leave room for substantial subjective in...

We unify several extensions of the classic Stone duality due to Grätzer, Hofmann–Lawson and Jung–Sünderhauf. Specifically, we show that $$\cup $$ -bases locally compact sober spaces are dual $$\prec -distributive $$\vee -predomains, where is a relation representing containment.

J Lipid Res. 2006 Nov;47(11):2475-81. Protective effect of apolipoprotein E2 on coronary artery disease in African Americans is mediated through lipoprotein cholesterol. Anuurad E, Rubin J, Lu G, Pearson TA, Holleran S, Ramakrishnan R, Berglund L. Department of Medicine, University of California, Davis, CA, USA. OBJECTIVE AND METHODS: We studied the relationship of apolipoprotein E (apoE) isofo...

in order to study the effects of post – anthesis heat stress on source of six wheat genotypes (vee/nac, chamran, s79-10, dez, fong and kaveer), two separate field experiments were conducted as delayed as against optimum sowing dates in ahvaz coditions. plants in delayed sowing date experienced heat stress at post-anthesis growth stage. as study of grain yield indicated that the highest and the ...

Precise subcellular localization is an important factor in regulation of the functions of protein tyrosine phosphatases. The non-receptor form of protein tyrosine phosphatase epsilon (cyt-PTP(epsilon)) can be found in cell nuclei, among other cellular locations, while p67 PTP(epsilon), a naturally occurring isoform which lacks the 27 N terminal residues of cyt-PTP(epsilon), is exclusively cytos...

A better understanding of the pathophysiological role of Langerhans cells (LC) in atopic diseases is dictated by the characterization of the structures involved in immunoglobulin (IgE)-binding on their cell surface. We previously reported that human LC express the high affinity receptor for IgE (Fc epsilon RI), as well as the low affinity receptor for IgE (Fc epsilon RII/CD23). In the present s...

A role for immunoglobulin E and its high affinity receptor (Fc epsilon RI) in the control of bacterial pathogenicity and intestinal inflammation has been suggested, but relevant animal models are lacking. Here we compare transgenic mice expressing a humanized Fc epsilon RI (hFc epsilon RI), with a cell distribution similar to that in humans, to Fc epsilon RI-deficient animals. In hFc epsilon RI...