In the present study we have isolated two splice variants of the organic anion transporting polypeptide 3A1 (OATP3A1_v1 and OATP3A1_v2) from human brain. OATP3A1_v2 lacks 18 amino acids at the C-terminal end (692 aa) but is otherwise similar in sequence as OATP3A1_v1 (710 aa). OATP3A1_v1 exhibits a wide tissue distribution with expression in testis, various brain regions, heart, lung, spleen, p...

In the present study we isolated two splice variants of organic anion transporting polypeptide 3A1 (OATP3A1_v1 and OATP3A1_v2) from human brain. OATP3A1_v2 lacks 18 amino acids (aa) at the COOH-terminal end (692 aa) but is otherwise similar in sequence to OATP3A1_v1 (710 aa). OATP3A1_v1 exhibits a wide tissue distribution, with expression in testis, various brain regions, heart, lung, spleen, p...

Introduction: Symptomatic intracranial xanthogranulomas mostly arise in the third ventricle, the choroid plexus of the lateral ventricle and the dura mater, showing hydrocephalus and neurological deficits due to mass effect . Pathological findings of central nervous system xanthogranulomas are not rare (1.6-7%) . Although case reports have shown that such lesions are occasionally associated wit...

background: previous studies have shown that morphine consumption during pregnancy may cause delay or defect of embryo development or abnormal nervous system function in the human and animal models. in the present study, the highest density of morphine accumulation in the central nervous system of rat embryos was evaluated using c14‑morphine. methods: female wistar rats (w 170‑200 g) used and w...

BACKGROUND AND PURPOSE Postoperative contrast-enhanced MR imaging of the brain is routinely used when evaluating for residual or recurrent brain tumor. It is imperative to be aware of morphologic changes and imaging features that typically occur in response to surgical manipulation at the postoperative site to avoid misinterpretation of imaging findings. Our purpose was to determine normal post...

The epithelial cells of choroid plexus (CP) in brain ventricles produce cerebrospinal fluid and act as the blood-cerebrospinal barrier. In this study, we confirmed that CP 4th ventricle is composed cellular oscillators all harbor glucocorticoid receptors are mutually synchronized to a robust clock gene expression rhythm detectable at tissue level vivo vitro . Animals lacking glucocorticoids (GC...

The choroid plexus epithelium of the brain ventricular system produces the majority of the cerebrospinal fluid and thereby defines the ionic composition of the interstitial fluid in the brain. The transepithelial movement of Na+ and water in the choroid plexus depend on a yet-unidentified basolateral stilbene-sensitive Na+-HCO3- uptake protein. Reverse transcriptase-polymerase chain reaction (R...