Abstract The transcription factor (TF) GRHL2 controls normal epithelial differentiation in different tissues. It is expressed all breast cancer subtypes except those with a mesenchymal phenotype (claudin-low subtype), where its ectopic expression leads to induction of mesenchymal-epithelial transition (MET) (1). Here we explored the mechanisms by which induces MET claudin-low cell lines using c...

Glycoconjugates involved in many functions are produced by cell types. This study aimed to investigate the glycoconjugate expression Oscar fish (Astronotus ocellatus) gills using five horseradish peroxidase-conjugated lectins. revealed that gill epithelial cells react with Canavalia ensiformis agglutinin (Con A) and Arachis hypogaea (PNA). Strong reaction Con A was seen of primary lamellae. Epi...

Objective(s): Non-invasive treatment options for retinoblastoma (RB), the most common malignant eye tumor among children, are lacking. Epithelial growth factor receptor (EGFR) accelerates cell proliferation, survival, and invasion of many tumors including RB. However, RB treatment by targeting EGFR has not yet been researched. In the current study, we investigated the effect of EGFR down-regula...

fumonisins, a family of mycotoxins, are mainly toxic and carcinogenic. the present study was carried out to evaluate fumonisin b1 (fb1) effects on the production of inflammatory cytokines by gastric and colon cell lines. the study was performed on two cell lines under in vitro condition, including gastric epithelial cell line (ags) and human colon adenocarcinoma cell line (sw742). lipopolysacch...

background & objectives:  cd10 is a cell surface enzyme with metalloendopeptidase activity, also known as common acute lymphoblastic leukaemia antigen, which mainly serves as a marker for acute lymphoblastic leukemia (all). to date and to the best of our knowledge, only few comparative immunohistochemical studies have assessed cd10 expression in cutaneous epithelial neoplasms. our goal was ...

background: gastric cancer (gc) is widely associated with chronic inflammation. the pro inflammatory microenvironment provides conditions that disrupt stem/progenitor cell proliferation and differentiation. the signal transducer and activator of transcription- 3 (stat3) signaling pathway is involved in inflammation and also contributes to the maintenance of embryonic stem cell (escs) pluripoten...

abstractgene therapy is a therapeutic approach to deliver genetic material into cells to alter their function in entire organism. one promising form of gene delivery system (dds) is liposomes. the success of liposome-mediated gene delivery is a multifactorial issue and well-designed liposomal systems might lead to optimized gene transfection particularly in vivo. liposomal gene delivery systems...

objective: acinetobacter baumannii (a. baumannii) has a good potential to colonize on various surfaces. as a virulence factor, adhesion to surfaces is the first step in colonization. the two-partner secretion system (tps) proteins are key factors for bacterial attachment. the purpose of this study is to identify and study the role of this family of proteins in adhesion of a. baumannii to human ...