I studied the effect of amiodarone, a cationic amphiphilic drug, on the cytokine release and protein kinase C (PKC) activity of mouse alveolar macrophages. In addition, I examined the relationship between amiodarone and eicosapentaenoic acid (EPA) with respect to the cytokine release. The decrease in cell number caused by amiodarone was depressed by pretreatment of the macrophages with EPA for ...

BACKGROUND Results from JELIS (Japan EPA Lipid Intervention Study) demonstrated the efficacy of pure eicosapentaenoic acid (EPA) in preventing coronary artery disease (CAD) in hypercholesterolemic patients under statin treatment. The present study examined in detail whether EPA is effective for the secondary prevention of CAD. METHODS AND RESULTS Patients with established CAD and a total chol...

PURPOSE We aimed to investigate the impact of nonsurgical periodontal treatment combined with one-year dietary supplementation with omega (ω)-3 on the serum levels of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA), and arachidonic acid (AA). METHODS Fifteen patients with chronic generalized periodontitis were treated with scaling and root planing. The tes...

cardiovascular disease (cvd) is the leading cause of death and disability in developed countries. atherosclerosis is the major cause of cvd, accounting for about half of the attributed deaths. cholesterol homeostasis is one of the most important factors in atherosclerosis. atp-binding cassette transporters cholesterol. omega (ω) 3 fatty acids are important ligands for regulation of abc transpor...

Satoh-Asahara et al. (1) recently reported that treatment with purified eicosapentaenoic acid (EPA; 1.8 g daily) for 3 months increases the serum EPA/arachidonic acid (AA) ratio and interleukin-10 levels of peripheral blood monocytes in association with slight decreases in the pulse wave velocity, an index of arterial stiffness, in obese patients with dyslipidemia. Pulse wave velocity values be...