We have identified a novel serine protease designated EOS by sequence identity searches. The deduced protein contains 284 amino acids with an active form containing 248 amino acids starting from an Ile-Val-Gly-Gly motif. The active form comprises a catalytic triad of conserved amino acids: His77, Asp126 and Ser231. It shares 44% identity with beta-tryptase and belongs to the S1 trypsin-like ser...

Eosinophils (Eos) are found at increased numbers within necrotic areas of tumors. We show that necrotic material from cell lysates containing damage-associated molecular pattern molecules induce eosinophil degranulation (release of major basic protein and eosinophil peroxidase) and enhance their oxidative burst while the stimulatory capacity of cell lysates is significantly diminished following...

Schizophrenia is widely regarded as the clinical outcome of aberrant neurodevelopment caused by a combination of genetic and non-genetic factors. Early Onset Schizophrenia (EOS) manifests in childhood or adolescence and represents a more severe variant of the Adult Onset form of the disorder (AOS). EOS offers a unique opportunity of exploring the impact of disease related mechanisms on the deve...

BACKGROUND Fraction of exhaled nitric oxide (Feno) and blood eosinophil count (B-Eos) values, markers of local and systemic eosinophilic inflammation, respectively, are increased in asthmatic patients. Little is known about the relation of these markers to reported wheeze and asthma events in a random population sample. OBJECTIVES We sought to determine the individual and independent values o...

Lampinen, M. 2000.Cytokine-regulated eosinophil migration in inflammatory disorders. Clinical and experimental studies. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 971. 60 pp. Uppsala. ISBN 91-554-4849-6. The accumulation of eosinophil granulocytes (EOS) at sites of inflammation is a common feature of asthma, allergic rhinitis an...

BACKGROUND The current review analyzes the long-term outcome and prognosis of early onset schizophrenia based on previously published studies in 1980. METHODS A systematic search of articles published in the English-language literature after 1980 identified a total of 21 studies, which included 716 patients who were either suffering from early onset schizophrenia (EOS) or both EOS and other p...

In this work, we confront ten cosmological models with observational H(z) data. The possible interaction between dark energy and dust matter is allowed in some of these models. Also, we consider the possibility of (effective) equation-of-state parameter (EoS) crossing −1. We find that the best models have an oscillating feature for both H(z) and EoS, with the EoS crossing −1 around redshift z ∼...

OBJECTIVES In schizophrenia, the most repeatable DTI findings concern reduced FA in temporal and frontal lobes with associated abnormalities in connecting neural fibers. The goal of study was to evaluate the differences in FA of the internal capsule in EOS-patients and healthy controls and to place emphasis on the sex as a potential factor determining a predominant pathological pattern of descr...

We study the evolution of supernova core from the beginning of gravitational collapse of a 15M⊙ star up to 1 second after core bounce. We present results of spherically symmetric simulations of core-collapse supernovae by solving general relativistic ν-radiation-hydrodynamics in the implicit time-differencing. We aim to explore the evolution of shock wave in a long term and investigate the form...

Properties of effective interactions in neutron-rich matter are reflected in the medium’s equation of state (EOS), which is a relationship among several state variables. Spin and isospin asymmetries play an important role in the energy balance and could alter the stability conditions of the nuclear EOS. The EOS has far-reaching consequences for numerous nuclear processes in both the terrestrial...