نتایج جستجو برای: enzymatic inhibition
تعداد نتایج: 378214 فیلتر نتایج به سال:
To improve our understanding of the prostate-specific antigen (PSA) antigenic regions, we studied the association targets of one anti-PSA polyclonal antibody and 10 anti-PSA monoclonal antibodies (mAbs). We also examined the ability of the mAbs to inhibit PSA enzymatic activity and block the association of PSA with alpha 1-antichymotrypsin (ACT). Linear epitope mapping with a polyclonal antibod...
An approach to an inhibition bioelectronic tongue is presented. The work is focused on development of an automated flow system to carry out experimental assays, a custom potentiostat to measure the response from an enzymatic biosensor, and an inhibition protocol which allows on-line detections. A Multi-commuted Flow Analysis system (MCFA) was selected and developed to carry out assays with an i...
The enzymatic activity of Bacillus subtilis glutamine synthetase (GS), which catalyzes the synthesis of glutamine from ammonium and glutamate, is regulated by glutamine feedback inhibition. The feedback-inhibited form of B. subtilis GS regulates the DNA-binding activities of the TnrA and GlnR nitrogen transcriptional factors. Bacterial GS proteins contain a flexible seven-residue loop, the Glu3...
Background and purpose: Telomerase activity has a major role in acute promyelocytic leukemia (APL). It also has a critical role in disease recurrence. This research aimed at studying the cytotoxic effects of telomerase inhibition using oligonucleotide-based molecule against human telomerase RNA template (hTERC antisense) and non-nucleoside small molecule targeting catalytic subunit (BIBR5132) o...
When laccases are applied for detoxifying steam-exploded slurries, enzymatic hydrolysis is affected. In this study, 10% (w/v) of dry weight (DW) slurry or water insoluble solid fraction were subjected to 48 h enzymatic hydrolysis in the presence of different laccase loadings (0.1, 0.5, 5 or 10 IU/g DW). All laccase dosages higher than 0.1 IU/g DW significantly inhibited glucose recovery. Nevert...
This study was aimed to analyze the effect of procyanidin B2 (PC) and tannin acid (TA) on activities cholesterol esterase (CEase) inhibitory mechanisms enzymatic activity. The interaction were investigated by kinetics, multi-spectroscopy methods, thermodynamics analysis, molecular docking, dynamic simulations. PC TA could bind with CEase inhibit activity enzyme in a mixed-competitive...
Background and Purpose The pathophysiology of coronary artery spasm (CAS), with its associated ischaemic crises, is currently poorly understood treatment frequently ineffective. In view increasing evidence that platelet-based defects may occur in CAS patients, we investigated platelet reactivity patients whether symptomatic crises reflect activation platelet–endothelial interactions. Experiment...
a b s t r a c t alzheimer's disease (ad) is a neurodegenerative disorder in geriatric people that characterized by reduction in memory and learning ability. attenuation of cholinergic system is the most likely hypothesis. therefore, potentiation of the cholinergic system via inhibition of acetylcholinesterase enzyme could improve and alleviate the symptoms of ad. a new series of isatin-based ...
Ezh2 (Enhancer of zeste homolog 2) protein is the enzymatic component of the Polycomb repressive complex 2 (PRC2), which represses gene expression by methylating lysine 27 of histone H3 (H3K27) and regulates cell proliferation and differentiation during embryonic development. Recently, hot-spot mutations of Ezh2 were identified in diffused large B-cell lymphomas and follicular lymphomas. To inv...
Unexplored electrochemical behavior of abiraterone, a recent and widely used prostate cancer drug, in interaction with cytochrome P450 3A4 (CYP3A4) enzyme and multiwalled carbon nanotubes (MWCNTs) is investigated in this work. The results reported in this work are significant for personalized medicine and point-of-care chemical treatment, especially to improve the life expectancy and quality of...
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