TAR DNA-binding protein (TDP-43) is a highly conserved and essential DNA- and RNA-binding protein that controls gene expression through RNA processing, in particular, regulation of splicing. Intracellular aggregation of TDP-43 is a hallmark of amyotrophic lateral sclerosis and ubiquitin-positive frontotemporal lobar degeneration. This TDP-43 pathology is also present in other types of neurodege...

Many studies were investigated to grade outdoor thermal comfort and related sensation during the past years. This study aims explore conditions in hot Mediterranean climate (Csa), which annually includes 1100–1700 cooling degree days 1200–1800 heating (CDD = 1100–1700, HDD 1200–1800). research tested human by applying Physiological Equivalent Temperature (PET) index. A field survey of 1230 inte...

ABSTRACT Mislocalization of the TAR DNA-binding protein 43 (TDP-43; encoded by TARDBP) from nucleus to cytoplasm is a common feature neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The downstream in vivo cellular effects this mislocalization are not well understood. To investigate impact mislocalized TDP-43 on neuronal cell ...

Introduction Many educational practitioners in the United Kingdom, working with the challenge of a diverse learning population, provide simplified language materials (SLMs) to their students (Barnard & Burgess, 2001; Rix, 2004, 2006). Their use in mainstream classrooms has not been evaluated however. This paper explores the manner in which teachers and support staff develop these SLMs. It repor...

Connexins proteins associate with a variety of catalytic and non-catalytic molecules. Also, different domains of connexin can bind to each other, providing a mechanism for channel regulation. Here, we review some of these associations, placing particular emphasis on the intramolecular interactions that regulate Connexin43 (Cx43). We also describe some novel methods that allow for the characteri...

PURPOSE This nonrandomized feasibility study was designed to provide a preliminary assessment of the impact of a narrative and vocabulary instruction program provided by a speech-language pathologist (SLP) in a regular classroom setting. METHOD Forty-three children attending 2 first-grade classrooms participated in the study. Children in each classroom were divided into high- and low-risk sub...