Hydration shells around proteins in solution are on average denser than bulk water. Variations in enthalpy are observed during hydration/dehydration of proteins. To explain consistently those phenomena, a common mechanism-electrostriction-underlying the mechanical and contributing to thermal effects is proposed. The mean mass density of the hydration shell of lysozyme derived from the neutron a...

The vaporization, fusion, and sublimation enthalpies of (R,S)- and (R)-flurbiprofen at T = 298.15 K are reported and compared with literature values when available. Correlation gas chromatography experiments were first performed to identify appropriate standards that could be used for materials containing a single fluorine substituent. Subsequent correlations resulted in a vaporization enthalpy...

Structural relaxation can be induced by annealing and usually leads to embrittlement in metallic glasses (MGs). Here, we show that a relaxed MG obtained an as-cast at temperature (annealing temperature, Ta) below its fictive suitably rejuvenated thermal treatment of the higher than Ta. The effect is driven enthalpy relaxation, endothermic reaction upon heating MG. This rejuvenation lifts energy...

Thermodynamic analysis provides access to the determinants of binding affinity, enthalpy and entropy. In fragment-based drug discovery (FBDD), thermodynamic analysis provides a powerful tool to discriminate fragments based on their potential for successful optimization. The thermodynamic data generated by FBDD studies can in turn be used to better understand the forces that drive biomolecular i...