نتایج جستجو برای: enhancers
تعداد نتایج: 6414 فیلتر نتایج به سال:
Enhancers control development and cellular function by spatiotemporal regulation of gene expression. Co-occurrence of acetylation of histone H3 at lysine 27 (H3K27ac) and mono methylation of histone H3 at lysine 4 (H3K4me1) has been widely used for identification of active enhancers. However, increasing evidence suggests that using this combination of marks alone for enhancer identification giv...
Embryonic development relies on the capacity of progenitor cells to appropriately respond to inductive cues, a cellular property known as developmental competence. Here, we report that epigenetic priming of enhancers signifies developmental competence during endodermal lineage diversification. Chromatin mapping during pancreatic and hepatic differentiation of human embryonic stem cells revealed...
Biological differences among metazoans and between cell types in a given organism arise in large part due to differences in gene expression patterns. Gene-distal enhancers are key contributors to these expression patterns, exhibiting both sequence diversity and cell type specificity. Studies of long-range interactions indicate that enhancers are often important determinants of nuclear organizat...
This paper reviews recent fi ndings about three skin penetration pathways (including a “polar pathway”) and four types of penetration enhancers (enzymes, vesicular systems, ceramides and chemical enhancers). This article will review possible ways for compounds to penetrate the skin and interact with it. Four families of enhancers will be discussed, along with their possible mechanisms of action...
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