We investigate the analytical representation of potentials of mean force (pmf) using the Morse/long-range (MLR) potential approach. The MLR method had previously been used to represent potential energy surfaces, and we assess its validity for representing free-energies. The advantage of the approach is that the potential of mean force data only needs to be calculated in the short to medium rang...

The complex between the tumor suppressor p53 and its down-regulator Mdm2 has been studied by dynamic force spectroscopy and the unbinding data have been analyzed in the framework of the Jarzynski theoretical approach. Accordingly, the unbinding equilibrium free energy has been determined from the work done along several non-equilibrium paths from the bound to the unbound state in the single mol...

This paper reviews top-down regulation analysis, a part of metabolic control analysis, and shows how it can be used to analyse steady states, regulation and homeostasis in complex systems such as energy metabolism in mitochondria, cells and tissues. A steady state is maintained by the variables in a system; regulation is the way the steady state is changed by external effectors. We can exploit ...

optimal attributes are useful in interpretation of seismic data. two proposed methods are presented in this paper for finding optimal attributes. regularized discriminate analysis(rda) is based on 2 parameters ë, ? which called regularization parameter. the other method is principal component analysi s(pca).in this paper gas chimney detection is defined as the subject of study for ranking relev...

In this research oxidation kinetic panceuo.s (P.S) by S2O8-2 at the presence of AgNO3 ascatalyst was studied.The method was spectrophotometer following absorption spectrum (P.S) inwave length of 518 nm. After improving the condition such as PH, P.S concentration, K2S2O8concentration, ionic strength, temperature, rate constant, activation energy, constant frequency,order reaction and thermo dyna...

In this paper, effects of ply orientation of adjacent plies with (ϕ//θ) interfaces on mode II critical strain energy release rate (fracture toughness) of multidirectional (MD) laminate has been studied. Ply orientation of adjacent plies is one of the most important parameters affects the mode II critical strain energy release rate () in the initiation of the delamination. To  study this paramet...

nowadays energy has significant role in socio economic development of counties; any decision on energy sector may affect the broad area in societies. system approach in energy modeling as an efficient method is known by many researchers in management and planning in a country particularly in energy sector. also system dynamics is one of the efficient methods, for reason unique ability at solvin...

In recent years, many different plans have been considered to use the nuclear energy gained from inertial confinement fusion (ICF) as attempts to obtain high energy efficiencies. In conventional ICF methods, a small amount (about mg) of the deuterium–tritium compound is confined in a small spherical chamber of a few millimeters in radius and compressed by laser or heavy ion beams with powers in...