BACKGROUND Inflammation is pivotal in atherosclerosis. A key early event in atherosclerosis is endothelial dysfunction. C-reactive protein (CRP), the prototypic marker of inflammation in humans, is a risk marker for cardiovascular disease, and there is mounting evidence to support its role in atherothrombosis. CRP has been shown to promote endothelial dysfunction both in vitro and in vivo. Emer...

The aim – to analyze the literature data sources concerning peculiarities of thecombined course chronic obstructive pulmonary disease (COPD) and coronaryheart (CHD), taking into account endothelial dysfunction systemicinflammation oxidative stress.Conclusions. main mechanisms involved in progression combinedcourse coronary heart are theendothelial dysfunction, systemic inflammation desynchronos...

Clinical manifestations of diabetic nephropathy are an expression of diabetic microangiopathy. This review revisits the previously proposed Steno hypothesis and advances our hypothesis that development of endothelial cell dysfunction represents a common pathophysiological pathway of diabetic complications. Specifically, the ability of glucose to scavenge nitric oxide is proposed as the initiati...

It is well known that endothelial dysfunction is a systemic disorder and a key variable in the initiation and progression of atherosclerosis and its complications.1 Most risk factors that are related to atherosclerosis and cardiovascular morbidity and mortality, including hypercholesterolemia, hypertension, cigarette smoking, and diabetes mellitus, are found to be associated with endothelial dy...

BACKGROUND GTP cyclohydrolase 1 (GCH1) deficiency is critical for endothelial nitric oxide synthase uncoupling in endothelial dysfunction. MicroRNAs (miRs) are a class of regulatory RNAs that negatively regulate gene expression. We investigated whether statins prevent endothelial dysfunction via miR-dependent GCH1 upregulation. METHODS Endothelial function was assessed by measuring acetylchol...

Coronavirus infection caused by the SARS-CoV-2 virus is a multifaceted disease due to generalized vascular endothelial damage. Endothelial damage also underlies COVID-associated coagulopathy. The paper presents case of coagulopathy causing myocardial infarction in 43-year-old patient with no history coronary disease. We have reviewed available literature for pathophysiological rationale assumed...

This Virulence special focus highlights the emerging critical role of endothelial activation and dysfunction in the pathogenesis of infectious diseases and associated clinical outcomes. Infectious disease investigators might ask why endothelial biology should be of interest to them. We hope that this special focus will make the research community think otherwise. The endothelium is comprised of...

INTRODUCTION The discovery of new treatments that prevent or treat preeclampsia would be a major advance. Antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sENG) are secreted in excess from the placenta, causing hypertension, endothelial dysfunction, and multiorgan injury. We recently identified metformin and esomeprazole as potential treatments for preecl...

Clinical manifestations of diabetic nephropathy are an expression of diabetic microangiopathy. This review revisits the previously proposed Steno hypothesis and advances our hypothesis that development of endothelial cell dysfunction represents a common pathophysiological pathway of diabetic complications. Specifically, the ability of glucose to scavenge nitric oxide is proposed as the initiati...

OBJECTIVE Atherosclerotic cardiovascular disease is the leading cause of death among people with diabetes. Generation of oxidized LDLs and reduced nitric oxide (NO) availability because of endothelial NO synthase (eNOS) dysfunction are critical events in atherosclerotic plaque formation. Biochemical mechanism leading from hyperglycemia to oxLDL formation and eNOS dysfunction is unknown. RESEA...