Oxygen tension and extracellular matrix compositions play important roles in network formation of endothelial cells. In article number 2006091, Yi-Chung Tung co-workers develop an vitro model using upside-down microfluidic device capable generating oxygen gradients for three-dimensional cell culture within hydrogels under controlled microenvironments.

vascular endothelial growth factor (vegf) is a multifunctional cytokine with distinct functions in angiogenesis, lymphangiogenesis, vascular permeability, and hematopoiesis. vegf is a highly conserved, disulfide-bonded dimeric glycoprotein of 34 to 45 kda produced by several cell types including fibroblasts, neutrophils, endothelial cells, and peripheral blood mononuclear cells, particularly t ...

Endothelial senescence entails alterations of the healthy cell phenotype, which accumulate over time and contribute to cardiovascular disease. Mechanical aspects regulating adhesion, force generation, response flow senescence-associated drift; however, they remain largely unexplored. Here, we exploit microscopy resolve variations anchoring substrate tractions generated upon aging in nanonewton ...

preeclampsia is an important pregnancy disorder with serious maternal and fetal complications which its etiology has not been completely understood yet. early diagnosis and management of disease could reduce its potential side effects. the vascular endothelial growth factor (vegf) family including vegf-a is the most potent endothelial growth factor which induces angiogenesis and endothelial cel...

endothelial dysfunction which is manifested by the loss of nitric oxide bioavailability, is an increasingly recognized cause of cardiac syndrome x (csx) and beta blockers are used for the treatment of this syndrome. thus, the aim of this study was to investigate effects of metoprolol, as a beta blocker, on endothelial function in csx patients. the study included 25 csx patients (20 female/ 5 ma...

background: this study attempted to determine the effects of long-term use of vitamin c on vascular endothelial function. materials and methods: during a pilot clinical trial study conducted at imam hussein hospital (isfahan) in 2014-2015, a total of 40 diabetic patients were selected and then assigned randomly into two 20-subject groups receiving vitamin c and placebo tablets. the patients wer...

background: recent evidences have supported migraine headache and neurally mediated syncope as the especial types of endotheliopathies. to determine endothelial function in patients with migraine headache or those with neurally mediated syncope,the present study was conducted. materials and methods: this cross-sectional study was performed on 93 consecutive patients aged 5-20 years in four grou...

Dehydroabietic acid (DHA) is an analog of abietic (AA) for cardiovascular disease prevention, known to act pharmacologically against aging, inflammation, bacterial infections and cancer. The current research investigated the molecular mechanisms DHA on adhesiveness endothelial leukocytes activation NF-κB in TNF-α treated HAEC ApoE−/− mice experimental atherosclerosis. HAECs were tested toxicity...