Background: Streptococcus agalactiae is the main causal pathogen of bovine mastitis (BM), causing considerable economic loss to the dairy industry worldwide. Vaccines against S. agalactiae play an important role in preventing disease. Aims: The aim of this study was to evaluate the immunoprotection of S. agalactiae pilus isla...

The aging-associated cellular and molecular changes in esophagus have not been established, yet. Thus we evaluated histological structure, interstitial cells of Cajal (ICCs), neuronal nitric oxide synthase (nNOS)-positive cells, and contractility in the esophagus of Fischer 344 rat at different ages (6-, 31-, 74-weeks, and 2-years). The lamina propria thickness and endomysial area were calculat...

Background: Rosacea is a chronic skin disease with an unknown etiology. Some reports have suggested an increased prevalence of Helicobacter pylori infection in rosacea patients, but it is controversial. This study was designed to compare the prevalence of H. pylori and serological cag A+ species between the rosacea patients and the healthy control group. Methods: This case-control study was per...

BACKGROUND/AIMS Celiac disease is an abnormal T cell-mediated immune response against dietary gluten in genetically predisposed individuals. The aim of our prospective study was to evaluate the frequency of Celiac disease in patients with lymphoma and to determine the usefulness of the anti-gliadin and anti-endomysial antibodies (EMA) for diagnosis of Celiac disease in this patient group. MET...

Sir, Serum IgA class anti-endomysial antibodies (EMA) are markers of coeliac disease and dermatitis herpetiformis (DH) and are useful in monitoring compliance to diet. Their overall sensitivity for the diagnosis of DH is about 80% and their specificity around 96% (1). As anti-gliadin antibodies (AGA) have already been reported in pemphigus (2, 3), the presence of AGA in another patient with pem...

BACKGROUND Breast cancer is the most common malignant neoplasm in the female population. However, stomach is a rare site for metastasis, and can show up many years after initial diagnosis and treatment of the primary tumor. AIM Analyze a case series of this tumor and propose measures that can diagnose it with more precocity. METHODS Were analyzed 12 patients with secondary gastric tumors. I...

BACKGROUND Serum antibody responses in humans to inactivated influenza A (H5N1), (H9N2) and A (H7) vaccines have been varied but frequently low, particularly for subunit vaccines without adjuvant despite hemagglutinin (HA) concentrations expected to induce good responses. DESIGN To help understand the low responses to subunit vaccines, we evaluated influenza A (H5N1), (H9N2), (H7N7) vaccines ...

Canine parvovirus (CPV) is a highly contagious pathogen that causes severe disease in dogs and wildlife. Previously, a panel of neutralizing monoclonal antibodies (MAb) raised against CPV was characterized. An antibody fragment (Fab) of MAb E was found to neutralize the virus at low molar ratios. Using recent advances in cryo-electron microscopy (cryo-EM), we determined the structure of CPV in ...

Leishmaniasis include several clinical manifestations, mostly cutaneous, visceral and mucosal (1, 2). Various species can lead to diverse clinical presentations. Thus species identification contribute to proper management (3). Localized Leishmania Lymphadenitis (LLL) is a distinct entity in clinicopathologic field presenting with isolated lymphadenitis and possible cocomitant cutaneous...

The 4-hydroxylation of mephobarbital enantiomers was investigated by using human liver microsomes from the extensive metabolizers (EM) and poor metabolizers of CYP2C19. The 4-hydroxylase activity of R-mephobarbital in the EM microsomes was >10 times higher than that of S-mephobarbital. In the poor metabolizer microsomes, the 4-hydroxylase activity of R-mephobarbital was much lower than that in ...