Ultrasonography of the endometrium is a noninvasive way to evaluate the chance of successful implantation during in vitro fertilization treatment. Ultrasound parameters of endometrial receptivity include endometrial thickness, endometrial pattern, endometrial volume, Doppler studies of uterine vessels and the endometrium. Endometrial thickness, pattern and volume are not predictive of pregnancy...

The histogenesis, pathogenesis, and endocrine background of endometrial cancer are reviewed. The histogenesis can be traced in graded steps through phases which have been designated as: 1) cystic hyperplasia, 2) adenomatous hyperplasia, 3) ana plasia, and 4) carcinoma in situ. A similar sequence of events has been observed in experimental animals when endometrial cancer was induced by the use o...

Objective. The aim was to assess the intraperitoneal spread of endometrial cells during hysteroscopy. Study Design. Seventy-six women were submitted to a hysteroscopy with CO(2) under a low pressure. Group 1 had not previous diagnosis of endometrial cancer, and group 2 had previous diagnosis of endometrial cancer (stage I-92.3%). Two peritoneal washing samples were taken before (PW1) and immedi...

OBJECTIVE This study was undertaken to evaluate the ability of preoperative endometrial sampling to accurately diagnose high-grade endometrial tumors. STUDY DESIGN Three hundred sixty endometrial cancer patients had preoperative endometrial sampling and hysterectomy specimens that underwent pathologic review at a single institution from 1995 to 2005. The sensitivity of Pipelle and curettage t...

Lau et al. authored a valuable article entitled “Impact of ovarian preservation in women with endometrial cancer”. This retrospective cohort study enrolled 529 patients with endometrial cancer between 2000 and 2010. Among these, 17 were in the ovarian preservation group and 517 in the bilateral salpingo-oophorectomy (BSO) group. The authors investigated the impact of ovarian preservation on the...

BACKGROUND It is well known that peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) plays an important role in tissue energy metabolism. However, the roles of PGC-1α in malignant endometrial cancer remain unknown. METHODS Forty cases of endometrial carcinoma, 15 cases with proliferative endometrial tissues, and 21 cases with normal endometrial tissues were collected...

introduction: this study was designed to investigate the characters of the human endometrial epithelial cells when cultured on either plastic or ecm (extracellular matrix) gel surface and to study ultrastructural features of cultured cells in comparison to endometrial tissue. material and methods: human endometrial tissue was obtained from patients who had undergone hysterectomy for uterine myo...

BACKGROUND Eukaryotic chromosomal ends are linear and are protected by nucleoprotein complexes known as telomeres. The complex structural anatomy and the diverse functions of telomeres as well as the unique reverse transcriptase enzyme, telomerase that maintains telomeres are under intensive scientific scrutiny. Both are involved in many human diseases including cancer, but also in ageing and c...

Endometrial biopsies are useful for evaluating endometrial disease, but the presence of non-endometrial, noncervical tissue is rare and is typically restricted to metastasis to the endometrial cavity. We report, for the first time, a case of an endometrial biopsy seeded with serous cells in a young patient with a known history of a serous borderline tumor of the ovary. Given the patient’s diagn...

Endometriosis is the abnormal growth of endometrial cells outside the uterus, causing pelvic pain and infertility. Furthermore, adhesion of endometrial tissue fragments to pelvic mesothelium is required for the initial step of endometriosis formation outside uterus. TGF-β1 and adhesion molecules importantly function for adhesion of endometrial tissue fragments to mesothelium outside uterus. How...