The review aims to comprehensively present the impact of exposure to endocrine disruptors (EDs) in relation to the clinical manifestation of obesity and related diseases, including diabetes mellitus, metabolic syndrome, cardiovascular diseases, carcinogenesis and infertility. EDs are strong participants in the obesity epidemic scenery by interfering with cellular morphological and biochemical p...

Most inborn errors of metabolism (IEM) are recessive, genetically transmitted diseases and are classified into 3 main groups according to their mechanisms: cellular intoxication, energy deficiency, and defects of complex molecules. They can be associated with endocrine manifestations, which may be complications from a previously diagnosed IEM of childhood onset. More rarely, endocrinopathies ca...

In the last few decades, a number of reciprocal associations between endocrine system dysfunctions and neurological or psychiatric manifestations have appeared, and only in the minority of the cases this link has been fully elucidated (1). Unfortunately, the complexity, and sometimes also the severity, of the clinical issues and the limited availability of reliable experimental models for the s...

Turner syndrome is a frequent chromosome disorder in clinical practice. It is characterized by short stature, gonadal dysgenesia and multisystemic involvement, responsible for a high morbidity and reduced life expectancy. The aim of the present paper is to describe the endocrinopathies and major problems at different ages, and to present suggestion for follow-up care in these patients.

Endocrine disrupting chemicals (EDCs) are linked to the worldwide epidemic incidence of metabolic disorders and fatty liver diseases, which affects quality life represents a high economic cost society. Energy homeostasis exhibits strong sexual dimorphic traits, organs respond EDCs depending on sex, such as liver, orchestrates both drug elimination glucose lipid metabolism. In addition, diseases...

Currently, non-infectious diseases, among which various disorders of the endocrine system play a decisive role, occupy one first positions in structure morbidity and mortality. Endocrine pathology worsens course other diseases is significant adverse factor increasing mortality, including cardiovascular accidents. Thyroid ranks second an increase incidence prevalence thyroid older age groups has...

609 IntroductIon Endocrine diseases have protean manifestations and present with a wide variety of symptoms pertaining to different bodily systems. This results, at times, in diagnostic delays and dilemmas; hence it is important for the clinician to be familiar with the neurological manifestations of endocrinopathies. Amongst various endocrinal disorders, the thyroid diseases are common and to ...

Diabetes mellitus is one of the most common endocrine diseases. Due to its complications, it caused significant mortality. Insulin and oral antidiabetic drugs were associated with many side effects. The search for more effective safer hypoglycemic agents important areas investigation. pharmacological investigations revealed that several medicinal plants showed effects by mechanisms. current rev...

It has been hypothesized over many years that the autoimmune endocrine diseases are each due to antigen-specific defects in suppressor (regulatory) T lymphocyte function. There is now increasing evidence in studies of autoimmune thyroid disease and insulin-dependent diabetes mellitus that suppressor cells are activated by irrelevant antigens but respond inadequately to specific relevant antigen...

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting 5-10 % of women of reproductive age. It generally manifests with oligo/anovulatory cycles, hirsutism and polycystic ovaries, together with a considerable prevalence of insulin resistance. Although the aetiology of the syndrome is not completely understood yet, PCOS is considered a multifactorial disorder with various gen...