نتایج جستجو برای: endocannabinoid

تعداد نتایج: 3595  

Journal: :Diabetes 2016
Laurent Demizieux Fabiana Piscitelli Stephanie Troy-Fioramonti Fabio Arturo Iannotti Simona Borrino Joseph Gresti Tania Muller Jerome Bellenger Cristoforo Silvestri Vincenzo Di Marzo Pascal Degrace

Evidence suggests that alterations of glucose and lipid homeostasis induced by obesity are associated with the elevation of endocannabinoid tone. The biosynthesis of the two main endocannabinoids, N-arachidonoylethanolamine and 2-arachidonoyl-glycerol, which derive from arachidonic acid, is influenced by dietary fatty acids (FAs). We investigated whether exposure to n-3 FA at a young age may de...

Journal: :Biology of reproduction 2006
Gilda Cobellis Giovanna Cacciola Donatella Scarpa Rosaria Meccariello Rosanna Chianese Maria Fosca Franzoni Ken Mackie Riccardo Pierantoni Silvia Fasano

N-arachidonoylethanolamide (anandamide [AEA]) is the main endocannabinoid described to date in the testis. It exerts its effects through the activation of G-protein coupled cannabinoid receptors (CNR). However, the activity of AEA in controlling male reproduction is still poorly known. Here we provide direct evidence on the presence of the "endocannabinoid system," constituted by type-1 cannabi...

Journal: :Cell metabolism 2012
Kwang-Mook Jung Jason R Clapper Jin Fu Giuseppe D'Agostino Ana Guijarro Dean Thongkham Agnesa Avanesian Giuseppe Astarita Nicholas V DiPatrizio Andrea Frontini Saverio Cinti Sabrina Diano Daniele Piomelli

The endocannabinoid system plays a critical role in the control of energy homeostasis, but the identity and localization of the endocannabinoid signal involved remain unknown. In the present study, we developed transgenic mice that overexpress in forebrain neurons the presynaptic hydrolase, monoacylglycerol lipase (MGL), which deactivates the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). M...

Journal: :Molecular Pharmacology 2010

Journal: :Philosophical Transactions of the Royal Society B: Biological Sciences 2014

Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2009
A Ribeiro V Ferraz-de-Paula M L Pinheiro J Palermo-Neto

The endocannabinoid system is involved in the control of many physiological functions, including the control of emotional states. In rodents, previous exposure to an open field increases the anxiety-like behavior in the elevated plus-maze. Anxiolytic-like effects of pharmacological compounds that increase endocannabinoid levels have been well documented. However, these effects are more evident ...

Journal: :Neuropharmacology 2009
Jason R Clapper Regina A Mangieri Daniele Piomelli

The endocannabinoid system modulates neurotransmission at inhibitory and excitatory synapses in brain regions relevant to the regulation of pain, emotion, motivation, and cognition. This signaling system is engaged by the active component of cannabis, Delta9-tetrahydrocannabinol (Delta9-THC), which exerts its pharmacological effects by activation of G protein-coupled type-1 (CB1) and type-2 (CB...

Journal: :Endocrine reviews 2006
Uberto Pagotto Giovanni Marsicano Daniela Cota Beat Lutz Renato Pasquali

During the last few years, the endocannabinoid system has emerged as a highly relevant topic in the scientific community. Many different regulatory actions have been attributed to endocannabinoids, and their involvement in several pathophysiological conditions is under intense scrutiny. Cannabinoid receptors, named CB1 receptor and CB2 receptor, first discovered as the molecular targets of the ...

2014
Daniela Laricchiuta Alessandra Musella Silvia Rossi Diego Centonze

Rewarding effects have been related to enhanced dopamine (DA) release in corticolimbic and basal ganglia structures. The DAergic and endocannabinoid interaction in the responses to reward is described. This study investigated the link between endocannabinoid and DAergic transmission in the processes that are related to response to two types of reward, palatable food and novelty. Mice treated wi...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید