Esophageal endoscopic submucosal dissection (ESD) is technically difficult. To make it safer, we developed a novel method using overtube with a traction forceps (OTF) for countertraction during submucosal dissection. We conducted an ex vivo animal study and compared the clinical outcomes between OTF-ESD and conventional method (C-ESD). A total of 32 esophageal ESD procedures were performed by f...

Electrostatic discharge (ESD) protection design for high-speed input/output (I/O) interface circuits in a 130-nm CMOS process is presented in this paper. First, the ESD protection diodes with different dimensions were designed and fabricated to evaluate their ESD levels and parasitic effects in gigahertz frequency band. With the knowledge of the dependence of device dimensions on ESD robustness...

polysilicon diodes to trigger ESD protection device is proposed to achieve excellent on-chip ESD protection. Design methodology of this novel ESD clamp circuit has been derived in detail. Some controlled factors in the novel ESD clamp circuit can be exactly calculated to design a suitable ESD clamp circuit for different power supply applications. By adding this efficient power-rail ESD clamp ci...

the aim of the present work was to assess the feasibility of accononmc8-2ep/nf as a bioadhesive material for developing controlled release gastroretentive microsponges of loratadine. modified emulsion-solvent diffusion method was employed for the preparation of microsponges (f1-f9) based on 32 factorial design. the amount of ethyl cellulose (ec) and polyvinyl alcohol (pva) were selected as inde...

We have systematically investigated the diffusion behavior of silica nanoparticles within supercritical ethanol, in terms of solvent properties by varying temperature (T) and pressure (P), to elucidate how the inhomogeneous solvent structures and density fluctuations in the solvent affect the diffusion behavior of solute particles. Results show that at a constant pressure, the diffusion coeffic...

Alginate based mineral oil entrapped emulsion gel (MOEG) buoyant beads of domperidone were prepared by emulsion gelation technique. The prepared beads were evaluated for particle size, surface morphology, buoyancy, actual drug content and entrapment efficiency. Effect of different oils (castor oil, olive oil and linseed oil) and oil concentrations (10%, 15% and 20%, w/w) on uniformity, homogene...

In the small intestine the nature of the environment leads to a highly heterogeneous mucus layer primarily composed of the MUC2 mucin. We set out to investigate whether the soluble dietary fibre sodium alginate could alter the permeability of the mucus layer. The alginate was shown to freely diffuse into the mucus and to have minimal effect on the bulk rheology when added at concentrations belo...

Abstract On-chip electrostatic discharge (ESD) protection circuits had been built in IC chips to protect the devices and circuits against ESD damage. But, ESD protection circuits constructed with the scaled-down CMOS devices are very weak to ESD stress. Therefore, novel ESD protection solutions must be developed to overcome this reliability challenge for integrated circuits fabricated in the na...

The pin-to-pin electrostatic discharge (ESD) stress was one of the most critical ESD events for differential input pads. The pin-to-pin ESD issue for a differential low-noise amplifier (LNA) was studied in this work. A new ESD protection scheme for differential input pads, which was realized with cross-coupled siliconcontrolled rectifier (SCR), was proposed to protect the differential LNA. The ...