1. Introduction Droplet concentration, size, polydispersity, and interfacial properties/interactions are key features which influence emulsion characteristics such as stability, texture and appearance [1]. Several techniques are available for measuring these features [2-6] however nuclear magnetic resonance (NMR) is particularly suited to studying the structure of emulsions because it is non-in...

Purpose: To study the effect of some factors on the size of finasteride nano-emulsion by chemometric approach which could predict the size of nano-emulsion droplets under different conditions. Methods: Nano-emulsions were prepared using spontaneous emulsification method which occurs when organic and aqueous phases are mixed. The organic phase was a homogeneous solution of oil (finasteride as a ...

We tested the hypothesis that the solvent for etomidate was a factor in the incidence of pain and other side effects after injection, and that these were associated with histamine release. Nine of 10 volunteers who received etomidate in a propylene glycol formulation reported moderate to severe pain on injection; only one of 10 subjects who received a lipid emulsion formulation reported mild pa...

BACKGROUND Microencapsulation is a useful method to prolong a drug release from dosage forms and to reduce its adverse effect (1) among various available methods. The microencapsulation of hydrophilic active ingredients requires the use of a polar dispersing phase such as a mineral oil. Acetone/paraffin systems are conventionally used. OBJECTIVES The current study aimed to investigate two dif...

The aim of this study is to formulate a novel ophthalmic nanosuspension (ONS), an alternative carrier system to traditional colloidal carriers for controlled release (CR) of acyclovir (ACV). In the present study, ONS is employed to avoid some of major disadvantages of colloidal carriers systems such as instability in cul de sac and short half life by increasing efficiency of drug encapsulation ...

The aim of the present work was to assess the feasibility of Acconon MC8-2 EP/NF as a bioadhesive material for developing controlled release gastroretentive microsponges of loratadine. Modified emulsion-solvent diffusion method was employed for the preparation of microsponges (F1-F9) based on  32 factorial design. The amount of ethyl cellulose (EC) and polyvinyl alcohol (PVA) were selected...

This work demonstrates the fabrication of surface-textured microcapsules formed from emulsion droplets, which are stabilized by an interlocking mesh needle-like crystals. Crystals small-organic-compound decane-1,10-bis(cyclohexyl carbamate) within geometric confinement through precipitation a binary-solvent-dispersed phase. binary mixture consists volatile solvent and nonvolatile carrier oil. C...

The oral absorption and hence the bioavailability of carbamazepine (CBZ) is variable even after administration rapidly dissolving formulation. This problem was attributed to supersaturation CBZ transformation less soluble dihydrate (CBD). Accordingly, formulation sustained release products a promising approach overcome this problem. Microsponges are an emerging which can help in direction. aim ...

KW-3902 (a newly synthesized adenosine A1-receptor antagonist) has potent diuretic and renal protective activities. We investigated the influence of the emulsion formulation on the pharmacokinetics of KW-3902 and its metabolite (M1) in rats using three different formulations, i.e., a lipid emulsion about 130 nm in diameter composed of egg yolk lecithin: soybean oil: oleic acid=1:1:0.048, a lipo...