The spectrum allocation policies of the Federal Communications Commission (FCC) [1] only allow spectrum access to primary users, it has been proven by various spectrum measurement campaigns that, the current spectrum usage across time and frequency is inefficient. Therefore, in order for the secondary users to access the unused portions of the licensed spectrum, the concept of “spectrum pooling...

In this article, the optical properties of silver cubic-shape nanostructures (SCNs) were analyzed by employing the discrete dipole approximation (DDA) in aqueous media. The absorption, dispersion and extinction cross-sections of these nanostructures were calculated based on the wavelength change of the incident light in the visible and near infrared region. Moreover, the height change, waveleng...

For a nite system A of bounded linear operators whose real linear combinations have real spectrum, the monogenic functional calculus is used to associate a function f(A) of the operators with any analytic function f in n real variables deened in a neighbourhood of the monogenic spectrum (A). Here, the existence of projection operators that decompose the functional calculus onto invariant subspa...

A method is presented for enhancing the narrowband interference rejection capability of direct-sequence spread-spectrum systems employing an adaptive notch filter. The method, based on projection onto convex sets, restores that part of the spread-spectrum signal distorted by the filter. Simulation results are presented which show the output bit-error rate (BER) improvement gained by using the s...

Loss of a functional mismatch repair (MMR) system in colorectal cancer (CRC) cells is associated with microsatellite instability and increased sensitivity to topoisomerase inhibitors. In this study, we have investigated whether a defect in double-strand break (DSB) repair by non-homologous end-joining (NHEJ) could explain why MMR-deficient CRC cells are hypersensitive to camptothecin (CPT), a t...

Homology-directed repair (HDR) of DNA double-strand breaks (DSBs) contributes to the maintenance of genomic stability in rodent cells, and it has been assumed that HDR is of similar importance in DSB repair in human cells. However, some outcomes of homologous recombination can be deleterious, suggesting that factors exist to regulate HDR. We demonstrated previously that overexpression of BCL-2 ...

Agrobacterium tumefaciens-mediated genetic transformation involves transfer of a single-stranded T-DNA molecule (T strand) into the host cell, followed by its integration into the plant genome. The molecular mechanism of T-DNA integration, the culmination point of the entire transformation process, remains largely obscure. Here, we studied the roles of double-stranded breaks (DSBs) and double-s...

In bacteria, double-strand break (DSB) repair via homologous recombination is thought to be initiated through the bi-directional degradation and resection of DNA ends by a helicase-nuclease complex such as AddAB. The activity of AddAB has been well-studied in vitro, with translocation speeds between 400-2000 bp/s on linear DNA suggesting that a large section of DNA around a break site is proces...

Radiation lethality is largely attributed to radiation-induced DNA double-strand breaks (DSBs). A range of structural complexity is predicted for radiation-induced DSBs. However, this lesion has never been analyzed in isolation at the molecular level. To address this problem, we have created authentic site-specific radiation-induced DSBs in plasmid DNA by triplex-forming oligonucleotide-targete...