نتایج جستجو برای: embryonic stem cells
تعداد نتایج: 1539279 فیلتر نتایج به سال:
This update discusses what is known regarding embryonic and adult tissue-derived pluripotent stem cells, including the mechanisms underlying self-renewal without senescence, differentiation in multiple cell types both in vitro and in vivo, and future potential clinical uses of such stem cells. In Section I, Dr. Lansdorp reviews the structure and function of telomerase, the enzyme that restores ...
To find a suitable feeder layer is important for successful culture conditions of bovine embryonic stem cell-like cells. In this study, expression of pluripotency-related genes OCT4, SOX2 and NANOG in bovine embryonic stem cell-like cells on mouse embryonic fibroblast feeder layers at 1-5 passages were monitored in order to identify the possible reason that bovine embryonic stem cell-like cells...
The current progress using the human embryonic stem cell (hESC) model system has provided much insight into the early origins of the hematopoietic and endothelial lineages, particularly the elusive hemangioblast. Recently, the cellular hierarchy and molecular regulation controlling hematopoietic commitment have been further elucidated. These findings not only provide new insights into early hum...
(Cell 184, 2020–2032.e1–e14; April 15, 2021) In the original version of this paper, we failed to include in author list Hongkui Deng, who made a critical contribution work by providing extended pluripotent stem cells. The online paper has been corrected. All co-authors have approved addition. We also cited preliminary manuscript deposited on bioRxiv (Aksoy et al., 2020) instead published study ...
Differences between individual DNA sequences provide the basis for human genetic variability. Forms of genetic variation include single nucleotide polymorphisms (SNPs), insertions/duplications, deletions, and inversions/translocations. The genome of human embryonic stem cells (hESCs) has been mainly characterized by karyotyping and comparative genomic hybridization (CGH), techniques whose relat...
objective: in vitro production of a definitive endoderm (de) is an important issue in stem cell-related differentiation studies and it can assist with the production of more efficient endoderm derivatives for therapeutic applications. despite tremendous progress in de differentiation of human embryonic stem cells (hescs), researchers have yet to discover universal, efficient and cost-effective ...
objective: the neural crest is a transient structure of early vertebrate embryos that generates neural crest cells (nccs). these cells can migrate throughout the body and produce a diverse array of mature tissue types. due to the ethical and technical problems surrounding the isolation of these early human embryo cells, researchers have focused on in vitro studies to produce nccs and increase t...
embryonic stem cells are capable of differentiating to variety of cell tissues including cardiomyocytes. this developmental change is accompanied with a great deal of ion channel expression and functions. mouse stem cell derived cardiomyocytes were prepared and separated to yield isolated single cell suspension for cell current recording. in the present study some properties of the k + -current...
Already in 2006 the group of Irina Klimanskaya / Robert Lanza had published a controversially discussed paper on the generation of human embryonic stem cells (hESCs) from cells that had been obtained by blastomere biopsy. Title and abstract of that paper suggested that removal of one or only few cells from an embryo could be sufficient, and that the original embryo might survive undamaged, so t...
Purpose: Parkinson's disease is a degenerative disease produced by the death of dopaminergic neurons, and the response to current treatments is varied. It is important to develop a model for the evaluation of ES cells as an alternative model for treatment. Materials and Methods: The model for PD was developed in rats. First, ES cells were transplanted into experimental models in three groups: ...
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