Programmed cell death (apoptosis) is an important mechanism that determines the size and shape of the vertebrate nervous system. Recent gene-targeting studies have indicated that homologs of the cell-death pathway in the nematode Caenorhabditis elegans have analogous functions in apoptosis in the developing mammalian brain. However, epistatic genetic analysis has revealed that the apoptosis of ...

The scientific reports on the successful use of Human Embryonic Stem cells to cure many sicknesses as provoked a long-standing controversy about ethics research involving human embryos. This arises from sharply differing moral views regarding embryos for purposes. Indeed, an earnest international scholarly debate continues till today over ethical, legal, and medical issues that arise in this ar...

introduction: stem cell biology has been the subject of much recent discussion. embryonic stem (es) cells, derived from the inner cell mass of the blastocyst stage of early mammalian embryos are expected to become a powerful tool in future regenerative medicine and developmental biology due to their capacity of self-renewal and pluripotency. in the present study, the ultrastructural development...

the use of quantum dots (qdots) as bright and photostable probes for long-term fluorescence imaging is gaining more interest. thus far, (pre)clinical use of qdots remains limited, which is primarily caused by the potential toxicity of qdots. most qdots consist of cd2+ ions, which are known to cause high levels of toxicity. therefore, the cytotoxic effects of cdse quantum dots on embryonic devel...

background avoidable mortality as an indicator for assessing the health system performance has caught the attention of researchers for a long time. in this study we aimed to compare the health system performance using this indicator in rural and urban areas of one of iran’s southern provinces.   methods all deaths (29916) which happened during 2004–2011 in bushehr province were assessed. nolte ...

Cell death is a common feature of neural development in all vertebrates. The bcl-2 proto-oncogene has been shown to protect a variety of cell types from programmed cell death. We have examined the distribution of bcl-2 protein in the developing and adult nervous systems. bcl-2 protein is widespread during embryonic development. Proliferating neuroepithelial cells of ventricular zones as well as...

Introduction. Male infertility is one of the main causes forced childlessness couples around world. Currently, a limited number drugs for treatment male are available on market. Biologically active supplements (dietary supplements) containing L-carnitine often used in complex therapy. The results determining therapeutic activity new drug, peptide obtained from cattle testes (PP-R-001) and compa...

Apoptosis-inducing factor (AIF) is an evolutionarily conserved, ubiquitously expressed flavoprotein with NADH oxidase activity that is normally confined to mitochondria. In mammalian cells, AIF is released from mitochondria in response to apoptotic stimuli and translocates to the nucleus where it is thought to bind DNA and contribute to chromatinolysis and cell death in a caspase-independent ma...

MLL rearrangements are hallmark genetic abnormalities in infant leukemia known to arise in utero. They can be induced during human prenatal development upon exposure to etoposide. We also hypothesize that chronic exposure to etoposide might render cells more susceptible to other genomic insults. Here, for the first time, human embryonic stem cells (hESCs) were used as a model to test the effect...