During segmentation of the Drosophila embryo, even skipped is required to activate engrailed stripes and to organize odd-numbered parasegments. A 16 kb transgene containing the even skipped coding region can rescue normal engrailed expression, as well as all other aspects of segmentation, in even skipped null mutants. To better understand its mechanism of action, we functionally dissected the E...

Since the three main pathways (the Wnt, VegT and BMP pathways) involved in organizer and axis formation in the Xenopus embryo are now characterized, the challenge is to understand their interactions. Here three comparisons were made. Firstly, we made a systematic comparison of the expression of zygotic genes in sibling wild-type, VegT-depleted (VegT(-)), beta-catenin-depleted (beta-catenin(-)) ...

BACKGROUND GnRH agonist (GnRHa) triggering has been shown to significantly reduce the occurrence of ovarian hyperstimulation syndrome (OHSS) compared with hCG triggering; however, initially a poor reproductive outcome was reported after GnRHa triggering, due to an apparently uncorrectable luteal phase deficiency. Therefore, the challenge has been to rescue the luteal phase. Studies now report a...

Mosaic aneuploidy and uniparental disomy (UPD) arise from mitotic or meiotic events. There are differences between these mechanisms in terms of (i) impact on embryonic development; (ii) co-occurrence of mosaic trisomy and UPD and (iii) potential recurrence risks. We used a genome-wide single nucleotide polymorphism (SNP) array to study patients with chromosome aneuploidy mosaicism, UPD and one ...

extended abstract 1. introduction one of the important issues in crisis management is providing settlement and help to the injured. in fact, the location of rescue and help centers should be designed in such a way that after the incident, there is the best chance ofgiving response to victims. in this regard, one of the important tasks of urban planners is to identify suitable locations for evac...

The WNK1 (WNK lysine deficient protein kinase 1) protein is a serine/threonine protein kinase with emerging roles in cancer. WNK1 causes hypertension and hyperkalemia when overexpressed and cardiovascular defects when ablated in mice. In this study, the role of Wnk1 in angiogenesis was explored using the zebrafish model. There are two zebrafish wnk1 isoforms, wnk1a and wnk1b, and both contain a...

trauma is a leading cause of death and disability especially amongst young people. road traffic crash–related death, injury, and chronic disability continue to be a major worldwide burden to drivers, pedestrians and users of mass transit, especially in low- and middle-income countries(lmic). projections predict worsening of this burden, and while motorization of lmic increases exponentially, a ...

objective: to evaluate the knowledge, attitude, and preparedness of mahabad red crescent society volunteers in dealing with chemical attacks. methods: this prospective cross-sectional study was conducted on 120 red crescent society volunteers in mahabad city, iran, during 2014-2015.the knowledge of the volunteers was evaluated and rated using a questionnaire as poor, moderate, and good. also, t...