Abstract Study question Does embryo biopsy for preimplantation genetic testing (PGT) followed by fresh or vitrified-warmed transfer affect children’s health up to 2 years of age? Summary answer Cleavage- blastocyst-stage vitrified-warmed-embryo had neither impact on anthropometry at birth, infancy childhood nor outcomes. What is known already Literature data regarding neonatal outcomes after PG...

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BACKGROUND The large number (30) of permanent human embryonic stem cell (hESC) lines and additional 29 which did not continue growing, in our laboratory at Karolinska Institutet have given us a possibility to analyse the relationship between embryo morphology and the success of derivation of hESC lines. The derivation method has been improved during the period 2002-2009, towards fewer xeno-comp...

In an effort to increase the credibility of human embryonic stem cell (hESC) lines established in Korea, obligatory registration was introduced by the Bioethics and Safety Act 2008, effective as of January 1, 2010. The DNA fingerprint, chromosome stability, expression of pluripotency markers, and contamination of mycoplasma of the submitted lines were analyzed by Korea Centers for Disease Contr...

during recent decades, the third person intervention in human artificial insemination has created new hopes for infertile couples. however these new progresses have propounded new ethical and legal concerns for families. one of them is confidentiality regarding gamete donor's identity, and its disclosure to the future child and others. of course, negligence to this ethical issue would produce a...

Embryo implantation depends on both embryo quality and the endometrial environment. Implantation failure has a complex, variable pathophysiology and is detrimental to the outcome of in vitro fertilization (IVF). Thus, patients with multiple implantation failure require an individualized approach to diagnosing and managing treatment options for future IVF cycles. These options should be based on...

Despite efforts made to improve the in vitro embryo culture conditions used during assisted reproduction procedures, human embryos must adapt to different in vitro oxygen concentrations and the new metabolic milieu provided by the diverse culture media used for such protocols. It has been shown that the embryo culture environment can affect not only cellular metabolism, but also gene expression...

Abstract Study question Does the placement of IVF embryo differ from implantation site? Summary answer At five weeks implanted has not moved in lateral plane endometrial cavity but is slightly lower vertical plane. What known already We previously showed that embryos approximately 9 mm fundus and equidistant tubal ostia highest rate. Whether migrates point where droplet deposited before controv...