A series of electron withdrawing or donating group substituted phenols were chemoselectively arylated with various substituted bromo-nitroarenes using KO(t)Bu at room temperature via an SNAr pathway. The synthesis of natural alkaloids (carbazoles), dibenzofurans, and a biaryl-indole was achieved from the synthesized nitro-biaryl-ols.

Remarkable generality in scope of new C9-benzoylcupreines bearing electron-withdrawing substituents for the nitroaldol condensation with fluoromethyl ketones is presented. Both tri- and difluoromethyl ketones provided excellent levels of stereoinduction (ee 76-99%) under mild reaction conditions and low loading of catalyst (1-5 mol%).

The novel isoquinolin-1-ylidene ligands, introduced into Rh(I) complexes by exploiting the carbene-like reactivity of adducts , exhibit ligand properties similar to those of classic NHCs, and their electronic properties can be tuned by the introduction of electron-withdrawing or donating groups in the benzene ring.

De-protected arabino N-glycosyl sulfamides, sulfonamides and sulfamates were found to mutarotate and convert from the furanose to the thermodynamically more stable pyranose form in aqueous solution. The presence of a strongly electron withdrawing group in the alkyl chain stopped mutarotation and furanose/pyranose equilibration, allowing the isolation of the first unprotected furanose N-glycosyl...

Diesel or jet fuel range branched alkanes were synthesized for the first time by the combination of hydroxyalkylation-alkylation (HAA) of 2-methylfuran with hydroxyacetone and subsequent hydrodeoxygenation. Due to the electron-withdrawing effect of the hydroxyl group, the hydroxyacetone route exhibited evident advantages (higher HAA reactivity and diesel yield) over the previous acetone route.

A new bacterial nitroreductase has been identified and used as a biocatalyst for the controllable reduction of a variety of nitroarenes with an electron-withdrawing group to the corresponding N-arylhydroxylamines under mild reaction conditions with excellent selectivity (>99%). This method therefore represents a green and efficient method for the synthesis of arylhydroxylamines.

Domino reactions of 2-methyl substituted chromones containing an electron withdrawing group at the 3-position with chromone-fused dienes synthesized a diverse range of benzo[a]xanthones and complicated chromone derivatives. These multiple-step reactions result in either two or three new C-C bonds without a transition metal catalyst or an inert atmosphere.

A series of 9-(pyridin-2'-yl)-aminoacridines was prepared and analyzed for their ability to change the thermal denaturation temperature of genomic calf thymus DNA. Development of a QSAR equation indicated that electron withdrawing groups on the pyridine ring promoted the interaction with double stranded DNA.

This paper describes the synthesis and catalytic testing of a palladium complex with 5-membered chelating [N,O] ligand, derived from condensation 2,6-diisopropylphenyl aniline maple lactone. catalyst was active towards Suzuki-Miyaura cross-coupling reaction, its activity optimised through selection base, solvent, loading temperature. The conditions are mild, occurring at room temperature over s...

Carbon nitride (C 3 N 4 ) is promising for photocatalytic hydrogen production, but photogenerated electrons and holes in C usually tend to exist as excitons due intrinsic Coulomb interactions making its activity unsatisfactory. Herein, a well-designed intramolecular -based donor-acceptor (D-A) system was constructed promote exciton dissociation. Due good chemical compatibility with melamine app...