Some neuroactive steroids which positively modulate GABAA receptor activity suppress cocaine-induced kindling but a possible involvement of other neurochemical mechanism in their antiepileptogenic effect remains to be elucidated. To this end, in the present study, we evaluated effects of allopregnanolone, a positive modulator of the GABAA receptor; its isomer without GABAergic activity--isopreg...

The aim of the study is to determine level HIF-1α, TNF-α, and NF-kB in hippocampus kindled rats treated with rapamycin axitinib.
 Materials methods. Kindling was produced 29 by administration three-week pentylenetetrazole (PTZ, 35.0 mg/kg, i.p.). Treatment (0.5 i.p.) axitinib (2.5 performed for ten days fully rats. avidin-biotin-peroxidase method used hippocampal slice staining. For negati...

The maternal form of modern rabbit crosses is obtained by crossing ancestral lines. Therefore it relevant to investigate the effect using males parental line Hyla cross with different weight indices on performance main breeding traits female rabbits cross. purpose study was level productivity reproduction signs and consider dynamics for a number births. experiments used 223 cross, which came fr...

Repeated administration of pentylenetetrazol (PTZ 30 mg/kg, thrice a week) to mice for 9 weeks and subsequent challenge of the animals with the same dose of PTZ on the last chronic dose produced chemical kindling. The mice showed myoclonic jerks, clonus, Straub’s tail, falling back response and full-blown convulsions. The anticonvulsant profile of chronic administration of BR16A (100 and 500 mg...

It is thought that cardiovascular changes may contribute to sudden death in patients with epilepsy. To examine cardiovascular alterations that occur during epileptogenesis, we measured the heart rate of rats submitted to the electrical amygdala kindling model. Heart rate was recorded before, during, and after the induced seizures. Resting heart rate was increased in stages 1, 3, and 5 as compar...

Introduction: Many studies have shown that amygdala kindling produces synaptic potentiation by induction of changes in the neuronal electrophysiological properties and inward currents both in epileptic focus and in the areas which are in connection with the epileptic focus and have important role in seizure development and progression such as hippocampal CA1 region. However, cellular mechani...

objective(s):a growing interest has recently been attracted towards the identification of plant-based medications including those with protective effects against cognitive impairment. sesamol has shown promising antioxidant and neuroprotective effects, therefore, we aimed to evaluate its therapeutic potential in epilepsy which is commonly associated with oxidative stress and cognitive impairmen...

Amygdala kindling is commonly used to study the mechanisms involved in epileptogenesis, with long-term amygdala kindling providing a useful model of the behavioural disturbances— such as heightened anxiety— that can occur between epileptic seizures. The purpose of this thesis was to determine whether increased fear behaviours exhibited by long-term amygdala kindled rats are reflective of previo...