background : lung cancer is still the leading cause of cancer- related deaths and most of themâ  are normally diagnosed in late stages, so there is an urgent need to establish reliable tools for the identification at early stages of the disease. in this study, we use an eleven gene signature test to examine lung biopsy specimens for diagnostic, prognostic & therapeutic purposes. methods : bronc...

objective(s): streptococcus pyogenes produces extracellular hyaluronidase enzyme. this enzyme is directly associated with the spread of the organism during infection. the objective of the present study was to clone and express the nucleotide sequence of the enzyme which is involved in hyaluronidase enzymatic activity. materials and methods: the enzymatic region of hyaluronidase gene was detecte...

resistin (retn), recently found to be relevant to inflammation and inflammatory disorders. we, therefore, aimed to investigate the potential role of retn gene polymorphism in pathogenesis of acne vulgaris with familial history. we investigated the retn-420c/g polymorphism in 180 patients with acne vulgaris and 180 healthy individuals in a case-control association analysis. in this study, we als...

anthracnose caused by colletotrichum gloeosporioides s. l. is one of the most important diseases of citrus in northern iran. to study the genetic structure of c. gloeosporioides s. l. from citrusspp., infected samples were collected from three citrus cultivating regions of northern iran, during the summer of 2009. fifty one monoconidial isolates were used as the objective of rep- and box-pcr fi...

introduction: antimicrobial peptides as the body's defense strategy play an important role in resistance against infection of microorganism. these peptides are able to modulate the immune and inflammatory processes through the production of defensive molecules. therefore, the modulatory effects of brevinin-2r, an antimicrobial peptide extracted from the skin of the frog (rana ridibunda), w...

influenza a viruses possesses two virion surface glycoproteins including haemagglutinin (ha) and neuraminidase (na). the na plays an important role in viral replication and promotes virus release from infected cells and facilitates virus spread throughout the body. to find out any genomic changes that might be occurred on na gene of avian influenza circulating viruses, we have genetically analy...

In this paper we recall two basic conjectures on the developables of convex projective curves, prove one of them and disprove the other in the first nontrivial case of curves in RP 3. Namely, we show i) that the tangent developable of any convex curve in RP 3 has degree 4 and ii) construct an example of 4 tangent lines to a convex curve in RP 3 such that no real line intersects all four of them...

We have produced human cyclin A in Escherichia coli and investigated how it generates H1 kistone kinase activity when added to cyclin-free extracts prepared from parthenogenetically activated Xenopus eggs. Cyclin A was found to form a major complex with cdc2, and to bind cdk2/Eg1 only poorly. No lag phase was detected between the time when cyclin A was added and the time when H1 histone kinase ...

how to cite this article: ghofrani m. lysosomal storage disease. iran j child neurol autumn 2012; 6:4 (suppl. 1):1-2.   for reading more pls see pdf