Plants produce potent constitutive and induced antifungal compounds to complement the structural barriers to microbial infection. Approximately 250,000-500,000 plant species exist, but only a few of these have been investigated for antimicrobial activity. Nevertheless, a wide spectrum of compound classes have been purified and found to have antifungal properties. The commercial potential of eff...

Background Widespread use of organophosphorous compounds (OPs) in agriculture and as nerve agents as well as a lack of clinically effective antidotes initiated the synthesis of new pyridinium bis-aldoximes (K-compounds) with high potency in reactivating acetylcholinesterase irreversibly inhibited by OPs [1,2]. We aimed to optimize an HPLC method sensitive enough to determine K-compounds from di...

OBJECTIVES There is an urgent need to develop a safe, effective, orally active, and inexpensive therapy for African trypanosomiasis due to the drawbacks of current drugs. Selective tubulin inhibitors have the potential to be promising drug candidates for the treatment of this disease, which is based on the tubulin protein structural difference between mammalian and trypanosome cells. We propose...

novel analogues of n-piperazinyl fluoroquinolones were prepared and evaluated against a panel of gram-positive and gram-negative bacteria, to study the effect of introducing bulky anthracene and phenanthrene moieties on the antibacterial effects of norfloxacin, ciprofloxacin and gatifloxacin. although most of the novel synthesized compounds had lower antibacterial effects, some derivatives show...

A suite of target endocrine disruptor compounds (EDCs) and pharmaceuticals and personal care products (PPCPs) were evaluated for removal by several water treatment processes at bench-, pilot-, and fullscale. Over 60 different EDCs and PPCPs were chosen and simultaneously evaluated based on structure, occurrence, and potential health impacts. Treatment processes evaluated include physical (e.g.,...

In this work some quantitative structure activity relationship models were developed for prediction of three bioenvironmental parameters of 28 volatile organic compounds, which are used in assessing the behavior of pollutants in soil. These parameters are; half-life, non dimensional effective degradation rate constant and effective Péclet number in two type of soil. The most effective descripto...

Phenolic and flavonoid compounds are secondary metabolites of plants which possess various activities such as anti-inflammatory, analgesic, anti-diabetes and anticancer effects. It has been established that these compounds can scavenge free radicals produced in the body. Because of this ability, not only the plants containing phenolic and flavonoid compounds but also, the pure compounds are use...

in this work some quantitative structure activity relationship models were developed for prediction of three bioenvironmental parameters of 28 volatile organic compounds, which are used in assessing the behavior of pollutants in soil. these parameters are; half-life, non dimensional effective degradation rate constant and effective péclet number in two type of soil. the most effective descripto...

lemon verbena (lippia citriodora) belongs tothe verbenaceae (shahpasand) family.l.citriodora is chemical  composition of the leaves plant have antimicrobial properties, refrigerant,anti-headaches one-sided, anti- pains nerve and housing, carminative, helping to digestion, relaxation, dizziness, colds therapy,  memory booster and etc.  in this study, phenolic compounds of l.citriodoraleaves were...

the leishmaniasis is a zoonotic disease that remains a severe public health problem and its burden is increasing. by now there is no anti-leishmaniasis vaccine and as other tripanosomial disease, is treated by limited drugs. first line drug includes pentavalent antimony such as sodium stibogluconat and meglumine antimoniate that use of these drugs is limited due to side effects, long term treat...