Two secreted signaling molecules, wingless (wg) and decapentaplegic (dpp), are required to specify the heart in Drosophila. wg and dpp are also required to specify other cell types within the mesoderm and in many other regions of the embryo. Because the spatial patterns of wg and dpp are dynamic, different populations of mesodermal cells are exposed to different combinations of wg and/or dpp at...

PURPOSE To investigate corneal thickness, curvature, and morphology with the Orbscan Topography System I (Bausch & Lomb, Inc., Salt Lake City, UT) in patients with Marfan syndrome (MFS) and to study MFS with in vivo confocal microscopy. METHODS This prospective, clinical, comparative case series included 60 eyes of 31 patients with MFS and 32 eyes of 17 control subjects. First, biomicroscopic...

The University of Padua is one of the most ancient in the world, being founded in 1222, and the most important anatomists of the XVI, XVII, and XVIII centuries studied and taught here. Probably, the first professor of anatomy and surgery was Bruno da Longobucco (c. 1200-c. 1286), who had previously studied at the Salerno School of Medicine. While professor in Padua, Andreas Vesalius (1514-1564)...

Sound synthesis with mass-interaction physical modeling networks can be considered as a general paradigm capable of being the central part of complete software environments for musical creation. GENESIS 3, built around the CORDIS-ANIMA formalism and developed by ACROE/ICA Laboratory, is the first environment of this kind. Using it, the artist may be facing an inherent problematic of every creat...

William Harvey and the Harveian Trust William Harvey was born in Folkestone on April 1, 1578. He was educated at the King’s School, Canterbury, Gonville, and Caius College, Cambridge, and the University of Padua, graduating as doctor of arts and medicine in 1602. He became a Fellow of the Royal College of Physicians in 1607 and was appointed to the Lumleian lectureship in 1615. In the cycles of...

During heart formation, a network of transcription factors and signaling pathways guide cardiac cell fate and differentiation, but the genetic mechanisms orchestrating heart assembly and lumen formation remain unclear. Here, we show that the small GTPase Cdc42 is essential for Drosophila melanogaster heart morphogenesis and lumen formation. Cdc42 genetically interacts with the cardiogenic trans...

We present the results of an experimental study of Haptic Digital Audio Effects with and without force feedback. Participants experienced through a low cost Falcon haptic device two new real-time physical audio effect models we have developed under the CORDIS-ANIMA formalism. The results indicate that the haptic modality changed the user’s experience significantly

Since colonial times emblems are used in Brazil as an important religious language. Among their diversity, the language of the “religio cordis” is outstanding and even gained a kind of sociological equivalent, called “cordial man” (Sérgio Buarque de Holanda). Alternative Protestant forms (G. de Montenay; D. Cramer) or Protestant adaptations of Catholic works have shown in Brazil no effect among...