نتایج جستجو برای: ebola virus

تعداد نتایج: 400131  

2014
Mateusz P. Karwowski Elissa Meites Kathleen E. Fullerton Ute Ströher Luis Lowe Mark Rayfield Dianna M. Blau Barbara Knust Jacqueline Gindler Chris Van Beneden Stephanie R. Bialek Paul Mead Alexandra M. Oster

Since early 2014, there have been more than 6,000 reported deaths from Ebola virus disease (Ebola), mostly in Guinea, Liberia, and Sierra Leone. On July 9, 2014, CDC activated its Emergency Operations Center for the Ebola outbreak response and formalized the consultation service it had been providing to assist state and local public health officials and health care providers evaluate persons in...

2015
Enrique Castro-Sánchez Elpiniki Spanoudakis Alison H. Holmes

Public involvement in efforts to control the current Ebola virus disease epidemic requires understandable information. We reviewed the readability of Ebola information from public health agencies in non-Ebola-affected areas. A substantial proportion of citizens would have difficulty understanding existing information, which would potentially hinder effective health-seeking behaviors.

Journal: :Rhode Island medical journal 2016
Jaclyn Skidmore Michael Gosciminski Utpala Bandy

BACKGROUND Ebola Virus Disease (Ebola) is a viral hemorrhagic fever that causes severe illness and can be fatal. Symptoms present 2 to 21 days after exposure to the Ebola virus and include: sudden onset of fever, severe headache, muscle pain, weakness, and fatigue, followed by vomiting, diarrhea, abdominal pain and unexplained bleeding or bruising.1 In December 2013, an outbreak of Ebola began ...

2014
Michelle S. Chevalier Wendy Chung Jessica Smith Lauren M. Weil Sonya M. Hughes Sibeso N. Joyner Emily Hall Divya Srinath Julia Ritch Prea Thathiah Heidi Threadgill Diana Cervantes David L. Lakey

Since March 10, 2014, Guinea, Liberia, and Sierra Leone have experienced the largest known Ebola virus disease (Ebola) epidemic with approximately 13,000 persons infected as of October 28, 2014. Before September 25, 2014, only four patients with Ebola had been treated in the United States; all of these patients had been diagnosed in West Africa and medically evacuated to the United States for c...

2015
Maulik R. Kamdar Michel Dumontier

Ebola virus (EBOV), of the family Filoviridae viruses, is a NIAID category A, lethal human pathogen. It is responsible for causing Ebola virus disease (EVD) that is a severe hemorrhagic fever and has a cumulative death rate of 41% in the ongoing epidemic in West Africa. There is an ever-increasing need to consolidate and make available all the knowledge that we possess on EBOV, even if it is co...

2017
Teresa Lambe Georgina Bowyer Katie J Ewer

Sporadic outbreaks of Ebola virus infection have been documented since the mid-Seventies and viral exposure can lead to lethal haemorrhagic fever with case fatalities as high as 90%. There is now a comprehensive body of data from both ongoing and completed clinical trials assessing various vaccine strategies, which were rapidly advanced through clinical trials in response to the 2013-2016 Ebola...

2014
Christopher E. McCoy Shahram Lotfipour Bharath Chakravarthy Carl Schultz Erik Barton

The 25th known outbreak of the Ebola Virus Disease (EVD) is now a global public health emergency and the World Health Organization (WHO) has declared the epidemic to be a Public Health Emergency of International Concern (PHEIC). Since the first cases of the West African epidemic were reported in March 2014, there has been an increase in infection rates of over 13,000% over a 6-month period. The...

2014
Aditya Sharma Nico Heijenberg Clement Peter Josephus Bolongei Bruce Reeder Tamba Alpha Esther Sterk Hugues Robert Andreas Kurth Angela Cannas Anne Bocquin Thomas Strecker Christopher Logue Antonino Di Caro Thomas Pottage Constanze Yue Kilian Stoecker Roman Wölfel Martin Gabriel Stephan Günther Inger Damon

Lofa County has one of the highest cumulative incidences of Ebola virus disease (Ebola) in Liberia. Recent situation reports from the Liberian Ministry of Health and Social Welfare (MoHSW) have indicated a decrease in new cases of Ebola in Lofa County. In October 2014, the Liberian MoHSW requested the assistance of CDC to further characterize recent trends in Ebola in Lofa County. Data collecte...

Journal: :Molecules 2017
James Schuler Matthew L Hudson Diane Schwartz Ram Samudrala

Ebola virus disease (EVD) is a deadly global public health threat, with no currently approved treatments. Traditional drug discovery and development is too expensive and inefficient to react quickly to the threat. We review published research studies that utilize computational approaches to find or develop drugs that target the Ebola virus and synthesize its results. A variety of hypothesized a...

Journal: :ACS infectious diseases 2016
Wouter A van der Linden Christopher J Schulze Andrew S Herbert Tyler B Krause Ariel A Wirchnianski John M Dye Kartik Chandran Matthew Bogyo

The recent Ebola virus outbreak in western Africa highlights the need for novel therapeutics that target Ebola virus and other filoviruses. Filoviruses require processing by host cell-derived cysteine cathepsins for productive infection. Here we report the generation of a focused library of cysteine cathepsin inhibitors and subsequent screening to identify compounds with potent activity against...

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