Neonatal sepsis is a leading cause of neonatal mortality. Congenital heart disease accounts for additional risk of sepsis in neonates. Here we report a case of Down's syndrome with late onset neonatal sepsis associated with multiple superficial skin abscesses simulating staphylococcal infection. The baby was empirically treated with vancomycin. Subsequently, multidrug resistant Klebsiella pneum...

Sepsis is a syndrome characterized by systemic inflammatory responses to a severe infection. Acute hyper-inflammatory reactions in the acute phase of sepsis have been considered as a primary reason for organ dysfunction and mortality, and advances in emergency intervention and improved intensive care management have reduced mortalities in the early phase. However it has been recognized that inc...

The clinical spectrum of sepsis, severe sepsis, and septic shock is responsible for a growing number of deaths and excessive health care expenditures. Until recently, despite multiple clinical trials, no intervention provided a beneficial outcome in septic patients. Within the last 2 years, studies that involved drotrecogin alfa (activated), corticosteroid therapy, and early goal-directed thera...

Background Early identification and treatment of sepsis is essential for prognosis and outcome. Sepsis is a complex syndrome based on non-specific symptoms, making early identification a medical challenge. Elevated or lowered bodytemperature often release a blood culture. Our hypothesis is, that a lack of temperature upon admission influence on the time of diagnosis and thereby time of antibiot...

Introduction Sepsis lacks a reliable measure of disease activity [1,2]. Therefore, it remains unclear how to monitor the response to treatment. Little is known about changes in vital signs during sepsis resuscitation and biomarkers for disease activity are not available to evaluate effects of treatment in sepsis patients at the bedside [2,3]. Trends in vital signs and biomarker levels during re...

PURPOSE To evaluate the diagnostic performance of maternal inflammatory marker: C-reactive protein (CRP) in predicting early onset neonatal sepsis (that occurring within 72 hours after birth). MATERIALS AND METHODS 126 low birth weight newborns (gestation 32±3.2 wk, birth weight 1887±623 g) and their mothers were included. Neonates were divided into sepsis group (n=51) including both proven (...

Septic shock is a common medical condition with a mortality approaching 50% where early diagnosis and treatment are of particular importance for patient survival. Novel biomarkers that serve as prompt indicators of sepsis are urgently needed. High-throughput technologies assessing circulating microRNAs represent an important tool for biomarker identification, but the blood-compartment specifici...

For the first time in medical history, a drug has been shown to reduce the mortality associated with sepsis, the leading cause of death in many ICUs. Optimal use by appropriate selection of patients and early recognition of sepsis could save thousands of lives. Nurses play a major role in recognizing severe sepsis. By using the concepts introduced here, nurses can play a direct role in saving t...

Background At Nykøbing Falster Hospital, a mid-size community hospital, sepsis is among the most frequent causes of death. International studies have shown significant reduction in mortality, morbidity and healthcare resource consumption with early screening and treatment of sepsis. The Acute Division wanted to identify possible areas of interventions that could improve the treatment of sepsis ...

Sepsis is a complication of severe infection characterized by a systemic inflammatory response. Mortality rates from sepsis range between 25% to 30% for severe sepsis and 40% to 70% for septic shock. The clinical presentation of sepsis is highly variable depending on the etiology. The most common sites of infection are the respiratory, genitourinary, and gastrointestinal systems, as well as the...