On the Relevance of Exchange Rate Regimes for Stabilization Policy This paper assesses the relevance of the exchange rate regime for stabilization policy. This regime question cannot be dealt with independently of other institutions, in particular how fiscal policy is designed. We show that once fiscal policy is taken into account, the exchange rate regime is irrelevant. This is the case indepe...

Objectives. 1) To determine the number of primary care clinic visits attributable to musculoskeletal pain (MSP) in children >3 and <15 years of age. 2) To describe the demographic characteristics of this population assessed for limb/back pain. 3) To characterize the etiology of musculoskeletal pain in an urban general pediatric clinic in Madrid, Spain. Methods. Prospective evaluation of 1000 co...

This special issue of JAMIA presents several applications of electronic health record (EHR) systems for clinical decision making. The integration of genetic information into EHRs has been receiving a lot of attention in the past few years. Wilcox et al (see page e117) describe the implementation of a user interface in an EHR that resulted in timely dissemination of gene variant information to c...

This paper analyzes the effectiveness of the tax and transfer systems in the European Union and the US to act as an automatic stabilizer in the current economic crisis. We find that automatic stabilizers absorb 38 per cent of a proportional income shock in the EU, compared to 32 per cent in the US. In the case of an unemployment shock 47 per cent of the shock are absorbed in the EU, compared to...

For decades, dimethyl sulfate (DMS) mapping has informed manual modeling of RNA structure in vitro and in vivo. Here, we incorporate DMS data into automated secondary structure inference using a pseudo-energy framework developed for 2 ́-OH acylation (SHAPE) mapping. On six non-coding RNAs with crystallographic models, DMSguided modeling achieves overall false negative and false discovery rates o...

The monoclinic unit cell of Bis(hydrazineH) pyrazine-2,3-dicarboxylate contains singly protonated hydrazine cations and doubly deprotonated pyrazine-2,3-dicarboxylate anions. Atoms forming the pyrazine ring are coplanar (r.m.s. 0.0075(1) Å). Carboxylate groups form dihedral angles with the pyrazine ring of 1.7(2)° (C7/O1/O2) and 89.3(2)° (C8/O3/O4). An extended hydrogen bond network is observed...

Proteins are classified as members of the APOBEC family based on the occurrence of a signature amino acid sequence and its characteristic three‐dimensional fold known as a zinc‐dependent deaminase domain (ZDD). This domain enables APOBEC proteins to bind nucleic acids and in most cases, deaminate cytidines. The ZDD coordinates a zinc atom necessary for hydrolytic deamination of cytosine or cyti...