Transcatheter aortic valve replacement (TAVR) has become the treatment of choice for many patients with isolated severe stenosis and is currently recommended by American College Cardiology/American Heart Association as a 1A recommendation.1Writing Committee M. Otto C.M. Nishimura R.A. et al.2020 ACC/AHA Guideline Management Patients With Valvular Disease: A Report Joint on Clinical Practice Gui...

sequence analysis as a single platform for routine clinical testing for NF1 Mattocks et al have used direct DNA sequencing and comparative sequence analysis to study patients with neurofibromatosis type 1 (NF1) and claim this study ‘‘achieved the highest recorded mutation detection rate using a single technique for this gene.’’ As a key point, the paper states that they studied 91 subjects fulf...

BACKGROUND AND OBJECTIVE There seems to be a strong causal relationship between allergy and the origins of asthma. Susceptibility to both is determined by a combination of genetics and environment acting through a complex network of cytokines. Nearly 90% of affected children have positive skin tests indicating the presence of specific immunoglobulin E (IgE), with sensitivity to house dust mite,...

Moline, H. E., Johnson, K. S., and Anderson, J. D. 1983. Evaluation of two-dimensional polyacrylamide gel electrophoresis of acidic proteins of ribosome preparations for identifying plant pathogenic soft-rotting bacteria. Phytopathology 73:224-227. Two-dimensional polyacrylamide gel electrophoretic separation of proteins ribosomal-enriched protein of Erwinia spp. were in those of the acidic was...

Neurons in primary visual cortex (area 17) respond vigorously to oriented stimuli within their receptive fields; however, stimuli presented outside the suprathreshold receptive field can also inf luence their responses. Here we describe a fundamental feature of the spatial interaction between suprathreshold center and subthreshold surround. By optical imaging of intrinsic signals in area 17 in ...

We previously established a y-ray dose-response curve for recessive lethal events (lethals) captured over the eTI balancer. In this paper we analyze the nature of lethal events produced, with a frequency of 0.04 per eTI region, at a dose of 1500 r. To do so, we developed a protocol that, in the absence of cytogenetics, allows balanced lethals to be analyzed for associated chromosomal rearrangem...

Objective. To examine the frequency, timing, and factors associated with abnormal cognitive and motor development during the first 30 months of life in infants born to women infected with human immunodeficiency virus type 1 (HIV-1). Methods. Serial neurodevelopmental assessment was performed with 595 infants born to women infected with HIV-1 in a multicenter, prospective, natural history cohort...

Colonoscopy has been shown to reduce incidence and mortality of colorectal cancer; however, its effectiveness is highly dependent on the quality.1Zauber A.G. Winawer S.J. O’Brien M.J. et al.Colonoscopic polypectomy long-term prevention colorectal-cancer deaths.N Engl J Med. 2012; 366: 687-696Crossref PubMed Scopus (1744) Google Scholar, 2Pilonis N.D. Bugajski M. Wieszczy P. al.Long-term cancer ...

We investigated the relationship between electrical alternans and cardiac electrical stability in a series of 20 dog experiments and in a pilot clinical study. Electrical alternans was detected in both the QRS complex and the ST-T wave by use of a novel multidimensional spectral technique. The magnitude of the alternation was expressed as the alternating electrocardiographic morphology index (A...

•Approximately two-thirds of patients with PLF-LG AS have severe aortic stenosis.•Multimodal evaluation is recommended in the group AS.•Patients PLF-LG-AS should be screened for cardiac amyloidosis. Severe stenosis (AS) defined as a mean transvalvular gradient (MG) ≥40 mm Hg or peak jet velocity (aortic Vmax) ≥4.0 m/sec, and an valve area (AVA) ≤1.0 cm2.1Otto C.M. Nishimura R.A. Bonow R.O. Cara...