CASE REPORT A66-year-oldwhitemanwith stage IIICmelanoma diagnosed in 2009 was treated with high-dose interferon alfa-2b for 1 year. He subsequently had subcutaneous and brainmetastases and underwent 2 cycles of high-dose interleukin-2 and whole-brain irradiation. Given disease progression, vemurafenib was initiated at 960 mg twice daily after testing confirmed the BRAF V600E mutation. After 4 m...

Supportive care of patients with functional neuroendocrine tumors (NETs) has evolved to include the use of multiple targeted agents to control paraneoplastic states and newer surgical and interventional radiologic techniques to reduce tumor bulk. Challenges encountered by the clinician are the recognition of specific symptom complexes, selecting the relevant laboratory tests and radiologic/scin...

OBJECTIVES Head trauma is a common cause of anosmia, but diagnosis is typically late, owing to more life-threatening sequelae of the injury. Herein, we describe our workup for a case of traumatic anosmia and the magnetic resonance imaging (MRI) findings both at the time of injury and at the 18-month follow-up. METHODS We present a case report and a review of the literature. RESULTS A 33-yea...

INTRODUCTION Antineoplastic chemotherapy remains one of the most widely used management strategies in cancer, either alone or in combination with other types of treatment. The main inconvenience of chemotherapy is its lack of selectivity, since it acts upon both tumor cells and rapidly multiplying normal cells such as bone marrow cells, hair follicle cells and oral and gastrointestinal mucosal ...

UNLABELLED INTRODUCTION Linezolid-induced black hairy tongue has been rarely reported. The purpose of this paper is to report a case of linezolid-induced black hairy tongue and review the literature. CASE PRESENTATION A 56-year-old Caucasian man was admitted with community-acquired pneumonia that failed to respond to levofloxacin 750mg daily. He was started on linezolid and meropenem and w...

This randomized, double-blind, placebo-controlled, parallel-group study was to determine the pharmacokinetic characteristics, safety, and tolerability of multiple doses of inhaled loxapine aerosol in subjects on a stable, oral, chronic antipsychotic regimen. Loxapine was delivered by means of a unique thermally generated aerosol comprising drug particles of a size designed for deep lung deliver...

Boceprevir is a first generation serin protease NS3/4A inhibitor, formally available in Italy from 2013 and often used for the treatment of CHC genotype 1, always in combination with pegylated interferon and ribavirin; known as the triple therapy. The main advantages of using boceprevir are the higher SVR percentage and shorter treatment time; 28 weeks if eRVR-extended rapid virological respons...

The objective of this study was to evaluate whether individuals with chronic renal failure (CRF) undergoing hemodialysis treatment have more salivary and oral mucosa alterations when compared healthy individuals, through a systematic review followed by meta-analysis. A literature performed, evaluating randomized clinical trials found in the Proquest, Embase, Scopus, Cochrane Library, Web Scienc...

Post COVID-19 syndrome, according to the WHO, is a disease that occurs in individuals with history of SARS-CoV-2 infection, usually within three months from its onset. It characterized by persistent clinical manifestations related sensory organs. The objective this review determine symptoms orofacial region Latin America emphasis on Andean region. A literature was conducted based publications 2...

Background: In recent years, the incidence of neoplastic diseases in children has increased significantly. Immunodepression triggers undesirable effects oral cavity such as mucositis, opportunistic infections, bleeding, xerostomia, dysgeusia, decay, dental malformations and pain. Objective: We aim to assess, through salivary tests, quality saliva pediatric patients affected by oncohematological...