Background: Memory loss is the main disorder accompanied by Alzheimer's disease (AD). Objectives: We aimed to investigate protective effects of aminoguanidine (Amg) on cell apoptosis in hippocampal CA1 region and memory impairment male rats received scopolamine (Scop). Methods: Thirty Wistar (200 - 250 g) were randomly divided into three groups saline-saline group, Scop + saline, Amg groups. Th...

To explore the effect of baicalin on cognitive function and nerves after splenectomy in aged rats is main objective study. Aged were randomly divided into a sham operation group, model group (to construct surgical model) treatment (baicalin was given constructed). The pathological conditions like interleukin-6, tumor necrosis factor alpha, interleukin-1 beta content; brain detection by terminal...

Abstract Doxorubicin, sold under the brand name Adriamycin among others, is an important drug for cancer therapy; however, its use limited by cardiotoxicity. Ginsenoside Rg2 extracted from Panax ginseng C.A.Mey., Araliaceae, which believed to have cardioprotective properties. However, date, there been no reports on whether ginsenoside could protect cardiomyocytes against doxorubicin. In this st...


 Purpose: To investigate the neuroprotective effect of ormosanine on rat model Alzheimer’s disease (AD), and mechanism(s) action involved.
 Methods: Rats were randomly assigned to 4 groups (10 rats/group): control group, AD 25 mg ormosanine/kg 50 group. (AD) was induced in rats via intracerebroventricular (ICV) injection amyloid-β (Aβ)25-35 at a concentration 1 mg/mL. Cognitive funct...

Introduction: This study aimed to show the potency of curcumin as an antiapoptotic agent that decreases the apoptotic index in the cochlea lateral wall in ototoxic rat models.   Materials and Methods: A total of 24 Rattus norvegicus were divided into eight groups: Group 1 (control group), Group 2 (gentamicin (+)), Group 3 (gentamicin + curcumin 20 mg/day), Group 4 (gentamicin + curcumin 40 ...

Purpose: The aim of the study explores probable toxic effects vancomycin on kidney and analysis protective melatonin.
 Materials Methods: In this study, rats were randomly divided into 4 groups: control group; melatonin (10 mg/kg/day) vancomycin-treated (200 mg/kg) + group. Rats in treatment group given two doses a day with an interval seven consecutive days once daily for days. experiment...

Purpose: To study the influence of etanercept on diabetic retinopathy in rats via tumor necrosis factor alpha (TNF-α)/nuclear kappa-light-chain-enhancer activated B cells (NF-κB) signaling pathway. 
 Methods: Thirty-six Sprague-Dawley (SD) were randomly divided into normal, model and groups. The expression Caspase-3 was determined by immunohistochemistry, while relative protein mRNA levels...