Introduction In this study, we contemplate to prepare a new type of scaffold which mimics natural bone and consists of three different components, namely biphasic polymeric base from two different biodegradable polymers prepared by using dual porogen approach, bioactive agents, i.e., collagen and hydroxyapatite (HA) particles which distributed throughout the scaffold only on the pore surfaces. ...

We prospectively reviewed 1000 consecutive patients who underwent a cementless, hydroxyapatite-coated, stemless, total knee replacement over a period of nine years. Regular post-operative clinical follow-up was performed using the Knee Society score. The mean pre-operative score was 96, improving to 182 and 180 at five and ten years, respectively. To date, there have been seven (0.5%) cases whi...

Strontium can be deposited in bone apatite either by the replacement of surface adsorbed calcium, or by substitution for intracrystalline calcium (1-3). It has also been reported that both of these processes favor the deposition of calcium to that of strontium (3). This report is concerned with the comparative incorporation of calcium and strontium in synthetic apatites. We shall present eviden...

Measurements were made of adsorption of a periphytic marine bacterium, glucose, and glutamic acid to inorganic particles in seawater and defined bacterial growth medium. Measurements of the metabolism of bacteria were made in the presence and absence of particles by microcalorimetry and radiorespirometry. It was found that hydroxyapatite adsorbs glutamic acid, but not glucose, from the experime...

We have investigated the pathway of prothrombin activation in blood and plasma. By means of a rapid purification procedure involving chromatography on DEAE-cellulose and hydroxyapatite, we demonstrated that the major prothrombin fragment in serum is that representing the amino-terminal half of prothrombin (i.e. F1-2). The F1-2 isolated was characterized by its size, amino acid and antigenic com...

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201; Institute of Ophthalmology, University College London, London EC1Y 8TB, United Kingdom; Departments of Surgery and Cancer and Materials, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom; Centre for Ophthalmology, University of Tübingen, D-72076 Tubingen, Ger...

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Remineralization is a fundamental mechanism for caries prevention and generally defined as crystal re-growth of hydroxyapatite in incipient caries lesions due to salivary calcium and phosphate. It is assumed, therefore, that the doses of salivary mineral components would be responsible for promotion of remineralization and could be a clinical biomarker to determine remineralization potential of...

Scattering scanning near-field optical microscopy (s-SNOM) has been demonstrated as a valuable tool for mapping the optical and optoelectronic properties of materials with nanoscale resolution. Here we report experimental evidence that trapped electric charges injected by an electron beam at the surface of dielectric samples affect the sample-dipole interaction, which has direct impact on the s...

Porous hollow spherical and rod-like silica nanoparticles were obtained via a surfactant templating method adopting hydroxyapatite (HAp) nanoparticles as an etchable core material.