The objective of this GLP study was to evaluate the safety and effectiveness of Adherus Dural Sealant and Adherus Spinal Sealant when used to achieve watertight dural closure in a canine lumbar durotomy repair model. Another important objective of this study was to determine whether Adherus Dural and Adherus Spinal Sealants would inhibit the formation of peridural fibrosis and dural adhesions a...

24 Approximately 20% of the adult population suffers from migraine. This debilitating 25 pain disorder is 3 times more prevalent in women than in men. To begin to evaluate 26 the underlying mechanisms that may contribute to this sex difference, we tested the 27 hypothesis that there is a sex difference in the inflammatory mediator (IM)-induced 28 sensitization of dural afferents. Acutely dissoc...

We report the case of a patient with situs inversus totalis, annuloaortic ectasia complicated by aortic insufficiency and mitral regurgitation which induced congestive heart failure. Both valvular lesions were repaired physiologically using aortic root sparing Yacoub 'remodeling' technique and mitral ring annuloplasty. Valve sparing techniques can be used effectively even in patients with compl...

A case of periductal mastitis and mammary duct ectasia is presented in a 50 year old male, with presenting symptoms similar to those of females, namely subareolar breast lump and mastalgia. As far as can be ascertained only 4 cases of mammary duct ectasia and periductal mastitis in males have been reported previously. Since this entity is not well known in males it is possible that it may be un...

Morning glory syndrome is a congenital anomaly of the posterior pole which is characterised by an ectasia of the posterior pole of the fundus involving the optic disc. In addition there is a slightly protruding pigment ring in the peripapillary area, and nonbranching veins protrude in radial formation from the ectasia. Recognition of veins and arteries is always difficult. The peripheral retina...

AIM The present study was designed to investigate mean platelet volume (MPV) values in coronary artery ectasia (CAE) patients in comparison with individuals with coronary artery disease and normal coronary angiograms. MATERIAL AND METHODS Patients with stable angina pectoris and scheduled for angiography were included in the study. Those with isolated coronary ectasia were evaluated in the co...

PURPOSE To evaluate changes in corneal topography indices after corneal collagen crosslinking (CXL) in patients with keratoconus and corneal ectasia and analyze associations of these changes with visual acuity. SETTING Cornea and refractive surgery subspecialty practice. DESIGN Prospective randomized controlled clinical trial. METHODS Corneal collagen crosslinking was performed in eyes wi...

PURPOSE To evaluate a series of patients with corneal ectasia after LASIK that underwent the Athens Protocol: combined topography-guided photorefractive keratectomy (PRK) to reduce or eliminate induced myopia and astigmatism followed by sequential, same-day ultraviolet A (UVA) corneal collagen cross-linking (CXL). METHODS Thirty-two consecutive corneal ectasia cases underwent transepithelial ...

Aim: Although underlying mechanisms of coronary artery ectasia (CAE) are clearly unknown, endothelial dysfunction may be responsible for the coronary ectasia. Asymmetric dimethylarginine (ADMA) is the principal endogenous inhibitor of nitric oxide synthase and elevated levels of ADMA is considered to be a marker of endothelial dysfunction and increased risk of cardiovascular disease. Accordingl...

This review outlines risk factors of post-laser in situ keratomileusis (LASIK) ectasia that can be detected preoperatively and presents a new metric to be considered in the detection of ectasia risk. Relevant factors in refractive surgery screening include the analysis of intrinsic biomechanical properties (information obtained from corneal topography/tomography and patient's age), as well as t...