نتایج جستجو برای: dual targeting
تعداد نتایج: 300248 فیلتر نتایج به سال:
We contribute to research on cooperative resilience by examining how their main advantage of social foundations may facilitate the assembly capabilities. Drawing from capital literature, we focus strategies and activities a nationally known rural in Indonesia reveal mechanisms, specifically channeling targeting capital, that underlie diverse sets By conceptualizing according cooperatives’ dual ...
in this paper, first we develop the duality concept for $g$-bessel sequences and bessel fusion sequences in hilbert spaces. we obtain some results about dual, pseudo-dual and approximate dual of frames and fusion frames. we also expand every $g$-bessel sequence to a frame by summing some elements. we define the restricted isometry property for $g$-frames and generalize some resu...
in this paper the concept of homothetic dual exponential motions in d3 is discussed and theirvelocities obtained. due to the way in which the matter is presented, the paper gives some formula and factsabout dual exponential motions which are not generally known
in this paper, two new hamilton operators are defined and the algebra of dual split quaternions isdeveloped using these operators. it is shown that finite screw motions in minkowski 3-space can be expressedby dual-number ( 3×3 ) matrices in dual lorentzian space. moreover, by means of hamilton operators, screwmotion is obtained in 3-dimensional minkowski space 3r1
Objective(s): Although low-dose radiotherapy (RT) that involves low collateral damage is more suitable for hepatocellular carcinoma (HCC) than traditional high-dose RT, but to achieve satisfactory therapeutic effect with low-dose RT, it is necessary to sensitize HCC cells to irradiation. This study was aimed to determine whether radiosensitivity of HCC cells can be enhanced using miR-26b by tar...
Nanomedicines In article 2201140 by Hsin-Cheng Chiu and co-workers, an oral polysaccharide microgel formulation containing dual-modality therapeutic nanoparticles developed for local treatment of colon cancer is imparted to hierarchical targeting residues, leading increases in retention cell uptake nanotherapeutics. With enzymatic degradation dextran microgels occurring exclusively the colon, n...
dAKAP1 (AKAP121, S-AKAP84), a dual specificity PKA scaffold protein, exists in several forms designated as a, b, c, and d. Whether dAKAP1 targets to endoplasmic reticulum (ER) or mitochondria depends on the presence of the N-terminal 33 amino acids (N1), and these N-terminal variants are generated by either alternative splicing and/or differential initiation of translation. The mitochondrial ta...
The rational design, synthesis and in vitro biological evaluation of dual action conjugates 11-13, containing a tumour targeting, integrin αvβ3/αvβ5 ligand portion and a pro-apoptotic SMAC mimetic portion (cyclo-RGD/SMAC mimetic conjugates) are reported. The binding strength of the two separate units is generally maintained by these dual action conjugates. In particular, the connection between ...
BACKGROUND Treatment of blast phase chronic myeloid leukemia (BP-CML) remains a challenge, and the median survival is less than 6 months. Because effective treatments are lacking, we studied tight targeting of blast crisis CML cells using adenoviral (Ad) vectors expressing a HSV-TK system under dual control of a specific SUZ12 promoter and an antioxidant response element (ARE). METHODS A pote...
Aberrant enzymatic activities or expression profiles of epigenetic regulations are therapeutic targets for cancers. Among these, histone 3 lysine 9 methylation (H3K9Me2) and global de-acetylation on histone proteins are associated with multiple cancer phenotypes including leukemia, prostatic carcinoma, hepatocellular carcinoma and pulmonary carcinoma. Here, we report the discovery of the first ...
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