We present efforts to mitigate debris from laser-produced Sn plasma by introducing a low energy pre-pulse while keeping high in-band conversion efficiency from laser to 13.5 nm extreme ultraviolet (EUV) light. The basic idea is to separate the processes of plasma production and 13.5 nm EUV light generation. A low energy pre-pulse is introduced to create a pre-plume; the main pulse then heats up...

AIM To detect abnormal microRNA (miRNA) expression in type 1 gastric neuroendocrine neoplasms (g-NENs) and find potential target genes. METHODS Tumour tissues from patients with type 1 g-NENs were used as experimental samples, and gastric mucosal tissues from the same patients obtained during gastroscopy review after several months were used as control samples. miRNA expression was examined w...

Dualor multi-target ligands have gained increased attention in the past years due to several advantages, including more simple pharmacokinetic and phamarcodynamic properties compared to a combined application of several drugs. Furthermore multi-target ligands often possess improved efficacy [1]. We present a new approach for the discovery of dual-target ligands using aligned pharmacophore model...

OBJECTIVE To assess the efficacy of two psychosocial interventions for caregivers of older persons with spinal cord injury (SCI). DESIGN A multisite, three-group, randomized controlled trial comparing two active intervention conditions with each other and to an information-only control group. One hundred seventy-three caregiver and care-recipient dyads were randomly assigned to one of three c...

Terrestrial laser scanners (TLS) are a class of 3D imaging systems that produce a 3D point cloud by measuring the range and two angles to a point. The fundamental measurement of a TLS is range. Relative range error is one component of the overall range error of TLS and its estimation is therefore an important aspect in establishing metrological traceability of measurements performed using these...

Conventional cytogenetic is the standard technique for detection of Philadelphia (Ph) chromosome in chronic myeloid leukemia (CML). Evaluation of abelson murine leukemia/breakpoint cluster region (abl/bcr) fusion using dual-colour fluorescence in situ hybridization (D-FISH) is an alternative approach allowing rapid and reliable detection of the disease. We employed the technique of interphase D...

BACKGROUND Blood product safety was significantly improved by the introduction of NAT testing in the late 1990s, resulting in a strong decrease of transfusion-transmitted infections (TTIs). Due to the occurrence of HIV-1 NAT test failures as a consequence of mismatch mutations in the amplicon regions of mono-target NAT assays, the Paul Ehrlich Institute mandated the implementation of multi-targ...

In this paper the abstract of the thesis ”New Interior Point Algorithms in Linear Programming” is presented. The purpose of the thesis is to elaborate new interior point algorithms for solving linear optimization problems. The theoretical complexity of the new algorithms are calculated. We also prove that these algorithms are polynomial. The thesis is composed of seven chapters. In the first ch...

Identification of the second of two targets is impaired if it is presented less than about 500 msec after the first This attentional blink (AB) occurs under dual-task conditions in which observers are required to report both targets. AB magnitude has been estimated by subtracting the accuracy scores in the dual task from the corresponding scores in a single task in which observers are instructe...

We extend the target map, together with the weighted barriers and the notions of weighted analytic centers, from linear programming to general convex conic programming. This extension is obtained from a novel geometrical perspective of the weighted barriers, that views a weighted barrier as a weighted sum of barriers for a strictly decreasing sequence of faces. Using the Euclidean Jordan-algebr...