BACKGROUND Daclatasvir (DCV) is an NS5A replication complex inhibitor recently approved for chronic hepatitis C virus treatment. METHODS To assess drug interactions between the HIV integrase strand transfer inhibitor dolutegravir (DTG) and DCV, subjects were randomized into 1 of 2 sequences in an open-label, 3-period, crossover study. Subjects received either DTG 50 mg once daily or DCV 60 mg...

a new category of hybrid organic-inorganic zirconium phosphonate, zr[(o3pch2)2nc6h4co2h].2h2o was synthesized and the applicability of the prepared sorbent as an ion-exchanger for removal of ni2+, cu2+ and zn2+ from aqueous solutions was evaluated. the characterization of the synthesis product was done using tg-dtg, sem, xrd, ft-ir techniques. study of the sorption isotherms and its kinetic par...

Coordination compounds of Co(II), Cu(II), Y(III), Zr(IV) and La(III) ions were synthesized from the N-salicylidene aniline (L) derived condensation with salicylaldhyde 1,10-phenanthroline (phen) as a secondary mixed ligand. L, phen their complexes characterized using various physiochemical methods, such elemental analyses (CHN), Fourier-transform infrared spectroscopy (FT-IR), molar conductance...

Spontaneously hypertensive heart failure (SHHF) rats develop hypertension and heart failure. We hypothesized that induction of hyperthyroidism should accelerate development of heart failure in male SHHF rats. Male and female SHHF rats received diets containing desiccated thyroid glands (DTG) or a control diet for 8 wk. Male and female Wistar-Kyoto rats were used as normotensive controls. DTG tr...

In this research, the nanosized Fe2V4O13 complex oxide material was synthesized by hydrothermal method. Its structure, morphology characterization, and other properties were determined using X-ray, SEM, EDX, DTA-TG methods. The catalytic activity of evaluated in terms decolorization degradation Indigo carmine dye. optimal condition for reusability catalyst determined. results showed that hetero...

Dolutegravir (DTG) is an HIV integrase inhibitor that was recently approved for therapy by the Food and Drug Administration in the United States. When used as part of first-line therapy, DTG is the only HIV drug that has not selected for resistance mutations in the clinic. We believe that this is due to the long binding time of DTG to the integrase enzyme as well as greatly diminished replicati...

The effect of high temperature on engineering properties rocks has recently become an important topic for geotechnical applications due to the development in geothermal energy extraction, underground coal gasification, disposal nuclear waste and deep mining applications. This study aims investigate four heated at temperatures identify corresponding mineralogical changes. Two types sandstone (Be...

Abstract Synthesis and characterization of sodium alginate from Sargassum aquifolium dan cinereum have been successfully performed. S. were collected the Dompu Islands, West Nusa Tenggara, Indonesia. Extraction was performed by acid pathway, due to cell disruption addition Na 2 CO 3 for extraction. The HCl convert into alginate, then transformed using NaOH. NaOCl IPA used purification. Physicoc...