PURPOSE To evaluate the concurrent validity of three European sets of drug-specific indicators of prescribing quality METHODS In 200 hip fracture patients (≥65 years), consecutively recruited to a randomized controlled study in Sahlgrenska University Hospital in 2009, quality of drug treatment at study entry was assessed according to a gold standard as well as to three drug-specific indicator...

The mainstay of diagnosis for Treponema pallidum infections is based on nontreponemal and treponemal serologic tests. Many new diagnostic methods for syphilis have been developed, using specific treponemal antigens and novel formats, including rapid point-of-care tests, enzyme immunoassays, and chemiluminescence assays. Although most of these newer tests are not yet cleared for use in the Unite...

Anti-cancer drug development involves enormous expenditure and risk. For rapid and economical identification of novel, bioavailable anti-tumour chemicals, the use of appropriate in vivo tumour models suitable for large-scale screening is key. Using a Drosophila Ras-driven tumour model, we demonstrate that tumour overgrowth can be curtailed by feeding larvae with chemicals that have the in vivo ...

Drug screening is the first phase of a drug development process taking 10 to 15 years for detecting potential drug candidates. Screening of candidates on drug targets is a random process and functions of drugs are not known in most trials, therefore traditional drug screening is not efficient and expedite process. In vitro nanomedicine and drug screening platforms provide significant contributi...

BACKGROUND Duchenne muscular dystrophy (DMD) is a devastating muscle wasting disease caused by mutations in dystrophin, a muscle cytoskeletal protein. Utrophin is a homologue of dystrophin that can functionally compensate for its absence when expressed at increased levels in the myofibre, as shown by studies in dystrophin-deficient mice. Utrophin upregulation is therefore a promising therapeuti...

INTRODUCTION Visits to settings such as emergency departments (EDs) may present a "teachable moment" in that a patient may be more open to feedback and suggestions regarding their risky alcohol and illicit drug-use behaviors. Screening, Brief Intervention, and Referral to Treatment (SBIRT) is an 'opportunistic' public health approach that targets low-risk users, in addition to those already dep...

Ultrasonography is an important modality that is frequently used in all aspects of breast imaging, including breast cancer screening, the evaluation of palpable abnormalities, further characterization of lesions seen mammographically, and for determining the method of percutaneous biopsy. Understanding the basic technical aspects of ultrasonography equipment is critical to ensure high breast ul...