Several therapeutic compounds have been identified that prolong the QT interval on the electrocardiogram and cause torsade de pointes arrhythmias not by direct block of the cardiac potassium channel human ether-à-go-go-related gene (hERG) but via disruption of hERG trafficking to the cell surface membrane. One example of a clinically important compound class that potently inhibits hERG traffick...

Paclitaxel (PTX), a chemotherapeutic drug, affects microtubule dynamics and influences endocytic trafficking. However, the mechanism and the dynamics of altered endocytic trafficking by paclitaxel treatment in single living cells still remain elusive. By labeling quantum dots (QDs) to the epidermal growth factor (EGF), we continuously tracked the endocytosis and post-endocytic trafficking of EG...

The study’s main objective was to evaluate the link between anti-money laundering (AML) regulations and financial sector development (FSD) in Africa test nonlinearities AML regulations-FSD nexus. Panel data of 51 African countries from World Bank’s indicators, IMF, Basel Institute on Governance over period 2012 2019 were used. study employs two-step system GMM dynamic panel threshold regression...

She has published extensively on organized crime, drugs, and illegal markets. In the 1990s, she served as consultant to the Italian Ministries of the Interior and Justice and the UNODCCP. The decade following the breakdown of the Soviet Union has registered a rapid growth of illegal drug use and trade in Russia. Illicit psychoactive substances were consumed even prior 1991, but the former USSR ...

In parasites, ATP-binding cassette (ABC) transporters represent an important family of proteins related to drug resistance and other biological activities. Here we report the characterization of LtrABCA2, a new ABC transporter of the ABCA subfamily in the protozoan parasite Leishmania tropica, localized at the flagellar pocket region and in internal vesicles. The overexpression of this transpor...

Despite the widely accepted assumption that most endosomal compartments are acidic, evaluation of the efficiency of pH-dependent drug release from a ligand-targeted drug conjugate during receptor-mediated endocytosis is lacking. Therefore, we have characterized the kinetics of pH-dependent drug release from a model folate-drug conjugate during folate receptor (FR)-mediated endosomal trafficking...

In the article it is analyzed process of criminalization Lebanese clans arrived in Germany early 1980s. It noted that was caused by a number reasons, including marginal situation immigrants, lack attention authorities to integration problems, specifics mentality, etc. Starting with petit thefts and street drug trafficking, gradually began create their own economic structures, which included bot...

The cardiac potassium channel hERG (human ether-a-go-go-related gene) encodes the alpha-subunit of the rapid delayed rectifier current I(Kr) in the heart, which contributes to terminal repolarization in human cardiomyocytes. Direct block of hERG/I(Kr) channels by a large number of therapeutic compounds produces acLQTS [acquired LQTS (long QT syndrome)] characterized by drug-induced QT prolongat...