In previous studies it has been demonstrated that the plant alkaloid voacamine (1), used at noncytotoxic concentrations, enhanced the cytotoxicity of doxorubicin and exerted a chemosensitizing effect on cultured multidrug-resistant (MDR) U-2 OS-DX osteosarcoma cells. The in vitro investigations reported herein gave the following results: (i) the chemosensitizing effect of 1, in terms of drug ac...

The major obstacles in intraperitoneal (i.p.) chemotherapy of peritoneal tumors are fast absorption of drugs into the blood circulation, local and systemic toxicities, inadequate drug penetration into large tumors, and drug resistance. Targeted theranostic nanoparticles offer an opportunity to enhance the efficacy of i.p. therapy by increasing intratumoral drug delivery to overcome resistance, ...

objective: serotonin reuptake inhibitors are frequently used in first-line treatments for patients ‎with obsessive-compulsive disorder. nevertheless, many of these patients do not ‎respond well to initial therapy. the hypothesis of glutamatergic dysfunction in specific ‎brain regions has been proposed in the pathophysiology of obsessive-compulsive ‎disorder. this study was designed to evaluate ...

conclusions carrier samples screening is considered inferior to clinical samples. treatment of a variety of infectious diseases is difficult due to resistant bacteria. consequently, annual screening of these individuals, detecting the carriers and decolonizing them to reduce transmission of s. aureus in the hospital are necessary. background methicillin-resistant staphylococcus aureus (mrsa) is...

introduction and aims: acinetobacter baumannii in recent decay has become an increasing concern in hospitals for its ability to acquire antibiotic resistance determinants rapidly and becoming resistant to almost all of the antibiotic classes. borage (echium amoenum  fisch. et mey), is a wild annual plant of boraginaceae family, grows in northern mountains of iran and has largely been used by ir...

Metastatic nonseminomatous testicular germ cell tumors are curable using combination chemotherapy in approximately 80% of patients. In contrast, most other patients with other types of cancer either present with or acquire drug-resistant disease following chemotherapy. Cell lines derived from testis tumors retain hypersensitivity to both drugs and radiation in vitro, thus providing a model syst...

Targeted therapies have advanced the treatment options for cutaneous melanoma, but many patients will progress on drug. Patient-derived xenografts (PDX) can be used to recapitulate therapy-resistant tumors. Furthermore, PDX modeling can be utilized in combination with targeted sequencing and phosphoproteomic platforms, providing preclinical basis for second-line targeted inhibitor strategies. S...