Spatiotemporal control over the delivery of therapeutic agents is an outstanding challenge to cancer treatment. By taking advantage of recent advances in DNA aptamer biology and mesoporous silica nanotechnology, we report a general approach to design and fabricate controlled release drug delivery systems that are able to effectively target cancer cells. Specifically, polyvalent mesoporous silic...

Nano-drug delivery systems have several advantages compared to the traditional forms of drugs. A nanocarrier sytem transport the drug to the site of action, hence, its influence on vital tissues and undesirable side effects can be minimized. Accumulation of therapeutic compounds in the target site increases and, consequently, the required doses of drugs are lower. Cell-specific targeting can be...

Viral contaminations speak to a general medical issue and one of the main sources worldwide mortality. A large portion antiviral medications have low permeability, dissolvability other related physical properties which make them less efficient for treatment. To conquer these constraints, different nanomedicine stages been planned. Nanomaterials offer special physico-chemical that various advant...

Nowadays the application of nanotechnology in different biomedical fields such as drug delivery is increasing due to its unique advantages. With this in mind, it is widely believed that nanogels as the nanometer-sized networked polymeric particles have a considerable impact on drug delivery systems as biocompatible nanocarriers due to their unique characteristics such as high loading capacity, ...

Heparin (Hep) conjugated to poly (amidoamine) dendrimer G3.5 (P) via redox-sensitive disulfide bond (P-SS-Hep) was studied. The redox and pH dual-responsive nanocarriers were prepared by a simple method that minimized many complex steps as previous studies. The functional characterization of G3.5 coated Hep was investigated by the proton nuclear magnetic resonance spectroscopy. The size and for...

Polyethylene glycol (PEG)-ylation is a widely used strategy to fabricate nanocarriers with a long blood circulation time. Further elaboration of the contribution of the surface PEGylation pattern to biodistribution is highly desirable. We fabricated a series of polyion complex (PIC) micelles PEGylated with different ratios (PEG2k and PEG550). The plasma protein adsorption, murine macrophage upt...

The application of nanotechnology to medicine constitutes a major field of research nowadays. In particular, the use of mesoporous silica and carbon nanoparticles has attracted the attention of numerous researchers due to their unique properties, especially when applied to cancer treatment. Many strategies based on stimuli-responsive nanocarriers have been developed to control the drug release ...

the application of chemotherapy in cancer treatment has been limited due to cause side effects such as toxicity against normal cells and drug resistance. in recent years, numerous studies have been focused on using natural products with chemotherapeutic drugs to enhance therapeutic efficiency and reduce cytotoxicity. on the other hand, encapsulation of drugs into nanoparticles (nps) can improve...

The aim of this paper is the preparation and characterization of drug delivery systems for a potential brain delivery by intranasal administration. It is possible to reach the central nervous system with alternative routes through which therapeutic agents can bypass the blood brain barrier: that is the nasal administration. Intranasal drug administration is non-invasive and it could be a promis...

The respiratory system, as well as the skin, are organs in direct contact with the environment and they represent possible doors for the entrance of therapeutic agents into the body. Because of the increasing incidence of pulmonary diseases with high mortality and morbidity, pulmonary drug delivery is emerging as a non-invasive and attractive approach for the treatment of several pathologies. I...