Usefulness of plasma drug monitoring in severe baclofen poisoning Cédric Cleophax, Antonio Goncalves, Céline Chasport, Eugénie de Beaugrenier, Laurence Labat, Xavier Declèves & Bruno Mégarbane To cite this article: Cédric Cleophax, Antonio Goncalves, Céline Chasport, Eugénie de Beaugrenier, Laurence Labat, Xavier Declèves & Bruno Mégarbane (2015) Usefulness of plasma drug monitoring in severe b...

OBJECTIVES This article will review current data on the metabolism, interactions, methods of analysis, and adverse effects observed with the use of new anticonvulsant drugs. The role of the laboratory in the provision of therapeutic drug monitoring for these drugs is discussed. CONCLUSION Certain of the newer anticonvulsant drugs require therapeutic drug monitoring for their optimal use in th...

The aim of this study was evaluation of enoxaparin utilization in hospitalized patients who had received enoxaparin either for prophylaxis or for treatment of thromboembolic disorders. A total of  356 patients were included in this retrospective study and were analyzed for enoxaparin utilization in terms of prescription patterns, treatment strategy, dosing regimen, indications/contraindica...

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In their recent large, retrospective, cross-sectional study with 7702 renal-transplant patients, Einollahi et al. showed that cyclosporine (CsA) absorption (CA) steadily increases over 3 years post transplant (1). They also indicated that despite the day-today and inter-in...

1. Reinshagen M, Schutz E, Armstrong VW, Behrens C, von Tirpitz C, Stallmach A, et al. 6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active Crohn disease: results from a randomized, controlled, open trial. Clin Chem 2007;53:1306–14. 2. Shipkova M, Armstrong VW, Wieland E, Oellerich M. Differences in nucleotide hydr...

BACKGROUND Voriconazole is a broad-spectrum, second-generation triazole antifungal agent with demonstrated efficacy in the treatment of invasive fungal infections caused by Aspergillus spp. and Candida spp. Given the characteristically poor prognosis of patients with invasive fungal infections and the protracted duration of treatment required, therapeutic monitoring of voriconazole is, in theor...

severe adverse drug reactions are an important cause of childhood morbidity and mortality. despite this, few reports in the literature describe it. this study was designed to evaluate the admitted pediatric patients due to adverse drug reactions. this retrospective study was conducted at pediatric ward of besat hospital. the records of hospitalized patients that admitted with diagnosis of adver...