BACKGROUND Medication errors cause a large number of adverse drug events with negative patient health outcomes and are a major public-health burden contributing to 18.7-56 % of all adverse drug events among hospitalized patients. The aim of this study was to assess the incidence and determinants of medication errors and adverse drug events among hospitalized children. METHODS A prospective ob...

OBJECTIVE Intravenous medications are vital during inpatient management. Errors associated with the administration of medications through intravenous infusion pumps to critically ill patients can result in adverse drug events. We sought to assess the impact of smart pumps with integrated decision support software on the incidence and nature of medication errors and adverse drug events. DESIGN...

BACKGROUND A common functional polymorphism, 5-HTTLPR, in the serotonin transporter gene has been associated with heavy drinking in college students. We examined this polymorphism as it interacted with negative life events to predict drinking and drug use in college students. METHODS Daily reports of drinking and drug use obtained using a daily web-based survey were combined with self-reports...

Tolerability of a drug should be regarded as important as its efficacy. In all four phases of drug development evaluation of adverse events is important. Recommendations for assessment of adverse events in acute and prophylactic clinical drug trials in migraine are given. Tolerability may be indirectly assessed using measures of general well-being and eight such tools are presented. Finally, re...

The low occurrence rate of adverse drug reactions makes it difficult to identify risk factors from a straightforward application of association pattern discovery in large databases. In this paper, we are interested in developing a data mining approach that can use the information about rare events in sequence data in order to measure the multiple occurrences of patterns in the whole period of t...

the purpose of present research was comparing tendency to risky behaviours in secure/insecure attachment in parents (mother/father). the results showed that those showing insecure attachment patterns towards the mother were significantly higher at risk to become cigarette smokers, drug persuasion, and alcohol drinkers compared to those with secure attachment patterns. those showing insecure att...

afghanistan as the largest producer of drug in the world, after the events of september 11, 2001, and attack of international forces following the resolution of the un, has been increasingly important in international politics. the range of effects from illigal drug trade in afghanistan and the countries on the way of transition and trafficking target market, has caused special attention paid t...

Drug toxicity and adverse drug events Pharmacogenomics, as applied to medical practice, offers the promise of reduction in adverse drug events (ADEs), enhanced drug efficacy and selection of patients able to respond to specific agents. This editorial will focus on the history and evolving role of pharmacogenetics and pharmacogenomics as it moves from the basic research laboratory into clinical ...

INTRODUCTION Patients initiated on highly active antiretroviral therapy (HAART) generally remain on medication indefinitely. A modification in the HAART regimen may become necessary because of possible acute or chronic toxicities, concomitant clinical conditions, development of virological failure or the advent of adverse drug events. The study documents adverse drug events of HIV-positive Ghan...