The therapeutic efficacy of systemic drug delivery vehicles is limited by their ability to evade the mononuclear phagocyte system, preferentially localize to the target tissue, and negotiate past the endothelial barrier. In order to create a delivery vehicle capable of all these functions, we developed a biomimetic functionalization of synthetic particles using membranes isolated from leukocyte...

Extracellular vesicles (EVs) are the substances that conveyed by most sorts of cell, which play a critical role in cell-to-cell communication. Exosomes among commonly explored EVs. contain lipids, RNAs and proteins. Many examinations have shown exosomes derived from cells different biological roles normal as well diseased condition. Recent investigations natural drug delivery vehicles, they abi...

This study fabricated novel multifunctional pH-sensitive nanoparticles loaded into microbubbles (PNP-MB) with the combined advantages of two excellent drug delivery vehicles, namely, pH-sensitive nanoparticles and microbubbles. As an antitumor drug, resveratrol (RES) was loaded into acetylated β-cyclodextrin nanoparticles (RES-PNP). The drug-loaded nanoparticles were then encapsulated into the ...

Among the available potential colloidal drug carrier systems, protein-based nanocarriers are particularly interesting. Meeting requirements such as low cytotoxicity, abundant renewable sources, high drug binding capacity and significant uptake into the targeted cells, protein-based nanocarriers represent promising candidates for efficient drug and gene delivery. Moreover, the unique protein str...

A [2]pseudorotaxane-based mechanised nanoparticle system, which operates within an aqueous acidic environment, has been prepared and characterised; this integrated system affords both water-soluble stalk and ring components in an effort to improve the biocompatibility of these promising new drug delivery vehicles.

A one-pot ultrasonic procedure has been developed as a versatile route for synthesizing polymer-coated microspheres that have potential application as drug delivery vehicles. The use of synthetic thiolated poly(methacrylic acid) macromolecules as the shell material offers control over size, morphology and functionality of the microspheres.

Supramolecular interaction is rapidly emerging as the method of choice for tuning molecular properties to meet desired applications like drug delivery vehicles, sensors, designing molecular architectures, catalysis chambers, biomimetic systems and so on. We have successfully demonstrated the modulation of electron and proton transfer reactions, acidbase characteristics and photophysical propert...

The objective of this study was to assess the transdermal delivery of drugs using iontophoresis with cation- and anion-exchange fibers as controlled drug delivery vehicles. Complexation of charged model drugs with the ion-exchange fibers was studied as a method to achieve controlled transdermal drug delivery. Drug release from the cation-exchange fiber into a physiological saline was dependent ...