نتایج جستجو برای: drosophila

تعداد نتایج: 69837  

2013
Ben Longdon Chuan Cao Julien Martinez Francis M. Jiggins

BACKGROUND Immune priming has been shown to occur in a wide array of invertebrate taxa, with individuals exposed to a pathogen showing increased protection upon subsequent exposure. However, the mechanisms underlying immune priming are poorly understood. The antiviral RNAi response in Drosophila melanogaster is an ideal candidate for providing a specific and acquired response to subsequent infe...

Journal: :Genetics 2002
Larisa Melnikova Pavel Georgiev

Telomeres of Drosophila melanogaster contain arrays of the retrotransposon-like elements HeT-A and TART. Terminally deleted chromosomes can be maintained for many generations. Thus, broken chromosome ends behave as real telomeres. It was previously shown that gene conversion may extend the broken ends. Here we found that the frequency of terminal DNA elongation by gene conversion strongly depen...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Celine Moorman Ling V Sun Junbai Wang Elzo de Wit Wendy Talhout Lucas D Ward Frauke Greil Xiang-Jun Lu Kevin P White Harmen J Bussemaker Bas van Steensel

Regulation of gene expression is a highly complex process that requires the concerted action of many proteins, including sequence-specific transcription factors, cofactors, and chromatin proteins. In higher eukaryotes, the interplay between these proteins and their interactions with the genome still is poorly understood. We systematically mapped the in vivo binding sites of seven transcription ...

Journal: :Molecular biology and evolution 1998
B Harr B Zangerl G Brem C Schlötterer

Fifteen microsatellite loci were studied in Drosophila melanogaster and Drosophila simulans, two closely related sibling species which split 2-3.5 MYA. Within-species variances in repeat number were found to differ up to 1,000-fold among individual microsatellite loci. A significant correlation of log variances between both species indicated a locus-specific mutation rate of microsatellites. He...

Journal: :Physiological genomics 2002
S Gorski M Marra

Programmed cell death (PCD) is an essential and wide-spread physiological process that results in the elimination of cells. Genes required to carry out this process have been identified, and many of these remain the subjects of intense investigation. Here, we describe PCD, its functions, and some of the consequences when it goes awry. We review PCD in the model system, the fruit fly, Drosophila...

2016
Mark A. Phillips Anthony D. Long Zachary S. Greenspan Lee F. Greer Molly K. Burke Bryant Villeponteau Kennedy C. Matsagas Cristina L. Rizza Laurence D. Mueller Michael R. Rose

Experimental evolutionary genomics now allows biologists to test fundamental theories concerning the genetic basis of adaptation. We have conducted one of the longest laboratory evolution experiments with any sexually-reproducing metazoan, Drosophila melanogaster. We used next-generation resequencing data from this experiment to examine genome-wide patterns of genetic variation over an evolutio...

Journal: :Genetics 2009
Jennifer A Anderson William D Gilliland Charles H Langley

While many functional elements of the meiotic process are well characterized in model organisms, the genetic basis of most of the natural phenotypic variation observed in meiotic pathways has not been determined. To begin to address this issue, we characterized patterns of polymorphism and divergence in the protein-coding regions of 33 genes across 31 lines of Drosophila melanogaster and 6 line...

Journal: :Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology 2005
Kathleen M Beckingham J Douglas Armstrong Michael J Texada Ravi Munjaal Dean A Baker

Drosophila melanogaster has been intensely studied for almost 100 years. The sophisticated array of genetic and molecular tools that have evolved for analysis of gene function in this organism are unique. Further, Drosophila is a complex multi-cellular organism in which many aspects of development and behavior parallel those in human beings. These combined advantages have permitted research in ...

Journal: :Genome biology and evolution 2015
Meng-Shin Shiao Jia-Ming Chang Wen-Lang Fan Mei-Yeh Jade Lu Cedric Notredame Shu Fang Rumi Kondo Wen-Hsiung Li

Drosophila sechellia relies exclusively on the fruits of Morinda citrifolia, which are toxic to most insects, including its sibling species Drosophila melanogaster and Drosophila simulans. Although several odorant binding protein (Obp) genes and olfactory receptor (Or) genes have been suggested to be associated with the D. sechellia host shift, a broad view of how chemosensory genes have contri...

Journal: :Molecular biology and evolution 2001
P Andolfatto

Surveys of molecular variation in Drosophila melanogaster and Drosophila simulans have suggested that diversity outside of Africa is a subset of that within Africa. It has been argued that reduced levels of diversity in non-African populations reflect a population bottleneck, adaptation to temperate climates, or both. Here, I summarize the available single-nucleotide polymorphism data for both ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید